Tissue-resident memory T cells play a key role in the efficacy of cancer vaccines

• Published in: Oncoimmunology Vol. 6; no. 11; p. e1358841
• Main Authors: Granier, C., Blanc, C., Karaki, S., Tran, T., Roussel, H., Tartour, E.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02-11-2017; Taylor & Francis Group
• Subjects: Author's View; cancer vaccine; immunosurveillance; resident memory T cell; route of immunization; tumor microenvironment; resident memory T cell; tumor microenvironment; cancer vaccine; immunosurveillance; route of immunization
• ISSN: 2162-4011; 2162-402X; 2162-402X
• DOI: 10.1080/2162402X.2017.1358841

Resident memory CD8
+
T cells (T
RM
) usually defined by the CD103 marker represent a new subset of long-lived memory T cells that remain in the tissues. We directly demonstrate their specific role in cancer vaccine-induced tumor regression. In human, they also seem to play a major role in tumor immunosurveillance.