Blinded, controlled field trial of two commercially available Mycoplasma bovis bacterin vaccines in veal calves

• Published in: Vaccine Vol. 29; no. 33; pp. 5347 - 5354
• Main Authors: Soehnlen, Marty K, Aydin, Adnan, Lengerich, Eugene J, Houser, Beth A, Fenton, Ginger D, Lysczek, Hannah R, Burns, Carolyn M, Byler, Louise I, Hattel, Arthur L, Wolfgang, David R, Jayarao, Bhushan M
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 26-07-2011; Elsevier; Elsevier Limited
• Subjects: Adjuvants, Immunologic - administration & dosage; Allergy and Immunology; Animals; antibodies; Antibodies, Bacterial - blood; Applied microbiology; arthritis; Bacteria; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - immunology; Bacteriology; Biological and medical sciences; Cattle; Cattle Diseases - immunology; Cattle Diseases - prevention & control; field experimentation; Fundamental and applied biological sciences. Psychology; immunoglobulin A; Immunoglobulin A - blood; immunoglobulin G; Immunoglobulin G - blood; immunoglobulin M; Immunoglobulin M - blood; industry; Injections, Subcutaneous; Lesions; Lung - microbiology; Lung - pathology; Microbiology; Milk; Miscellaneous; morbidity; Mycoplasma bovis; Mycoplasma bovis - immunology; Mycoplasma Infections - immunology; Mycoplasma Infections - prevention & control; Mycoplasma Infections - veterinary; otitis; pneumonia; relative risk; Respiratory diseases; Respiratory infection; Respiratory tract; Respiratory Tract Diseases - immunology; Respiratory Tract Diseases - prevention & control; Respiratory Tract Diseases - veterinary; sodium chloride; Tuberculosis; vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); veal; Veal calf; veal calves; United States > US; Bacteria; Veal calf; Mycoplasma bovis; Respiratory infection; Bovine; Respiratory disease; Zoopathogen; Vaccine; Mycoplasmataceae; Mollicutes; Mycoplasmatales; Vertebrata; Mammalia; Artiodactyla; Veterinary; Ungulata
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.05.092

Mycoplasma bovis is an etiologic agent of pneumonia, arthritis, and otitis in young calves, such as those found in the special-fed veal industry. We conducted a blinded, controlled trial of two commercially available M. bovis bacterin vaccines for the prevention of respiratory disease in calves associated with M. bovis infection. Calves were randomly assigned to a subcutaneous treatment of vaccine A (n=50), adjuvant A (n=50), vaccine B (n=50), or 0.9% sterile saline solution (n=50) beginning at 27 days of age. Upper-respiratory tract colonization was not impacted by vaccination status. Vaccine A significantly reduced the presence of lung lesions (p=0.0325), however there was no significant reduction of M. bovis in lung lesions. Vaccine B did not significantly reduce total lung lesions or M. bovis-specific lung lesions. The relative risk was determined to be 0.56, 1.0, and 1.36 for vaccine A, adjuvant A, and vaccine B, respectively. There was no association between the total specific antibody isotype (IgM, IgG1, IgG2, IgA) concentrations or M. bovis antibodies and the M. bovis-associated morbidity in the veal calves. Under the field conditions of this study, observed vaccine efficacy for vaccine A and vaccine B was 44% and less than 1%, respectively.