Effects of chronic caloric restriction on kidney and heart redox status and antioxidant enzyme activities in Wistar rats

• Published in: BMB reports Vol. 45; no. 11; pp. 671 - 676
• Main Authors: Dutra, Marcio Ferreira, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, Bristot, Ivi Juliana, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, Batassini, Cristiane, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, Cunha, Nubia Broetto, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, Kuckartz Vizuete, Adriana Fernanda, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, de Souza, Daniela Fraga, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, Fonseca Moreira, Jose Claudio, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil, Goncalves, Carlos-Alberto, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society for Biochemistry and Molecular Biology 01-11-2012; 생화학분자생물학회
• Subjects: Animals; Antioxidants - metabolism; Caloric Restriction; Carbonylation; Catalase - metabolism; Dietary reduction; ESTRES OXIDATIVO; FOOD INTAKE; Heart - physiopathology; INGESTION DE ALIMENTOS; Kidney - physiopathology; Male; Oxidation-Reduction; OXIDATIVE STRESS; PRISE ALIMENTAIRE (HOMME); Protein Carbonylation; Rats; Rats, Wistar; STRESS OXYDATIF; Superoxide Dismutase - metabolism; 화학
• ISSN: 1976-6696; 1976-670X
• DOI: 10.5483/BMBRep.2012.45.11.094

Caloric restriction (CR) has been associated with health benefits and these effects have been attributed, in part, to modulation of oxidative status by CR; however, data are still controversial. Here, we investigate the effects of seventeen weeks of chronic CR on parameters of oxidative damage/modification of proteins and on antioxidant enzyme activities in cardiac and kidney tissues. Our results demonstrate that CR induced an increase in protein carbonylation in the heart without changing the content of sulfhydryl groups or the activities of superoxide dismutase and catalase (CAT). Moreover, CR caused an increase in CAT activity in kidney, without changing other parameters. Protein carbonylation has been associated with oxidative damage and functional impairment however, we cannot exclude the possibility that, under our conditions, this alteration indicates a different functional meaning in the heart tissue. In addition, we reinforce the idea that CR can increase CAT activity in the kidney.