The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation

• Published in: Heliyon Vol. 6; no. 3; p. e03577
• Main Authors: Allahveisi, Azra, Seyedoshohadaei, Fariba, Rezaei, Masomeh, Bazrafshan, Narges, Rahimi, Kaveh
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-03-2020; Elsevier
• Subjects: Clinical research; Frozen embryo transfer; Health sciences; Implantation; Obstetrics and gynecology; Pharmacology; Platelet-rich plasma; Pregnancy; Reproductive system; Women's health; Pregnancy; Health sciences; Frozen embryo transfer; Platelet-rich plasma; Clinical research; Implantation; Pharmacology; Reproductive system; Obstetrics and gynecology; Women's health
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2020.e03577

The aim of this study was to evaluate the effect of platelet-rich plasma (PRP) on the rate of implantation and pregnancy in women with repeated failed implantation during frozen embryo transfer.
This study was conducted on 50 infertile women candidates (who were referred to the Infertility Treatment Center of Besat Hospital in Sanandaj) with a history of failed implantation for the purpose of frozen embryo transfer. The participants were randomly divided into two groups (n = 25). In the first group (control), the intrauterine infusion of 0.5 ml of Ringer serum was done 48 h before embryo transfer. In the second group (treatment), the intrauterine infusion of 0.5 ml of PRP was performed 48 h before embryo transfer.
In this study, there was no significant difference between the two groups in the rate of chemical and clinical pregnancy. The rate of chemical pregnancy was 28% in the treatment group and 36% in the control group, while the rate of clinical pregnancy was 28% in the treatment group and 24% in the control group.
The intrauterine infusion of PRP before frozen embryo transfer in infertile women with a history of failed implantation will not make any significant effect on the result of pregnancy.
Obstetrics and gynecology; Health sciences; Pharmacology; Women's health; Reproductive system; Clinical research; Platelet-rich plasma, Frozen embryo transfer, Implantation, Pregnancy.