Hourly analysis of cerebrospinal fluid glucose shows large diurnal fluctuations

• Published in: Journal of cerebral blood flow and metabolism Vol. 36; no. 5; pp. 899 - 902
• Main Authors: Verbeek, Marcel M, Leen, Wilhelmina G, Willemsen, Michèl A, Slats, Diane, Claassen, Jurgen A
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-05-2016
• Subjects: Aged; Aged, 80 and over; Brief Communication; Cerebrospinal Fluid - chemistry; Cerebrospinal Fluid - physiology; Circadian Rhythm - physiology; Eating - physiology; Female; Glucose - cerebrospinal fluid; Humans; Male; Middle Aged; Monitoring, Physiologic; Time Factors; glucose transport; glucose; Cerebrospinal fluid; plasma; diurnal
• ISSN: 0271-678X; 1559-7016
• DOI: 10.1177/0271678X16637612

Cerebrospinal fluid analysis is important in the diagnostics of many neurological
disorders. Since the influence of food intake on the cerebrospinal fluid glucose
concentration and the cerebrospinal fluid/plasma glucose ratio is largely
unknown, we studied fluctuations in these parameters in healthy adult volunteers
during a period of 36 h. Our observations show large physiological
fluctuations of cerebrospinal fluid glucose and the cerebrospinal fluid/plasma
glucose ratio, and their relation to food intake. These findings provide novel
insights into the physiology of cerebral processes dependent on glucose levels
such as energy formation (e.g. glycolysis), enzymatic reactions (e.g.
glycosylation), and non-enzymatic reactions (e.g. advanced endproduct
glycation).