Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis

• Published in: Heliyon Vol. 6; no. 6; p. e04248
• Main Authors: Zaraket, Rasha, Salami, Ali, Bahmad, Marwan, El Roz, Ali, Khalaf, Batoul, Ghssein, Ghassan, Bahmad, Hisham F.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-06-2020; Elsevier
• Subjects: Adenovirus; Antibiotic resistant bacteria; Children; Clinical research; Diarrhea; Gastroenteritis; Gastrointestinal system; Infectious disease; Laboratory medicine; Lebanon; Rotavirus; Virology; Lebanon; Infectious disease; Rotavirus; Laboratory medicine; Adenovirus; Gastrointestinal system; Gastroenteritis; Diarrhea; Clinical research; Children; Antibiotic resistant bacteria; Virology
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2020.e04248

Acute gastroenteritis is a very common infectious disease facing all age groups worldwide, especially the pediatric population. Viruses, bacteria, and parasites are all possible causes of infectious gastroenteritis; however, viruses have become more frequently identified with the advances in the ability to diagnose viral infections, particularly rotavirus and adenovirus. We aimed in our study to compare between the prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among children with viral gastroenteritis in Lebanon.
A 12-months retrospective study was performed between January 1st and December 31st, 2018 including 308 children aged 1 month to 12 years, who were admitted to three tertiary healthcare centers in South Lebanon. Medical data were retrieved from patients’ files, including clinical and laboratory information.
Rotavirus was found in stool of 204 patients (66.23 %), followed by adenovirus in 78 cases (25.32 %), and mixed group (rotavirus and adenovirus) in 26 cases (8.44%). The highest prevalence of rotavirus in our present study was seen among children between 12 and 23 months old, whereas patients infected with adenovirus were mainly aged between 24-35 months or 4–11 months. Majority of patients in the adenovirus and mixed groups had high-grade fever compared to the rotavirus group. Laboratory findings presented significantly higher average of white blood cells (WBCs), absolute neutrophil count (ANC), and C-reactive protein (CRP) in the mixed group compared to the two other groups. Monthly distribution of rotavirus and adenovirus infection revealed a biennial pattern of rotavirus incidence during January and July–August while frequency of adenovirus infection was highest during July–August.
Due to the high prevalence of viral diarrhea among the pediatric age group in our region, particularly rotavirus and adenovirus, along with the associated non-specific signs and symptoms, we highly recommend that medical laboratories be equipped for virus detection. Also, vaccination against rotavirus should be considered as a prevention strategy.
Gastrointestinal system; Infectious disease; Antibiotic resistant bacteria; Virology; Laboratory medicine; Clinical research; Rotavirus; Adenovirus; Gastroenteritis; Children; Diarrhea; Lebanon.