Serum uric acid and risk of cardiovascular mortality: a systematic review and dose-response meta-analysis of cohort studies of over a million participants

• Published in: BMC cardiovascular disorders Vol. 19; no. 1; p. 218
• Main Authors: Rahimi-Sakak, Fatemeh, Maroofi, Mahsa, Rahmani, Jamal, Bellissimo, Nick, Hekmatdoost, Azita
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15-10-2019; BioMed Central; BMC
• Subjects: Cardiovascular diseases; Cardiovascular diseases mortality; Cohort; Complications and side effects; CVD mortality; Death; Longitudinal; Mortality; Obesity; Purines; Risk factors; Serum uric acid; Uric acid; Serum uric acid; Longitudinal; Uric acid; Cohort; CVD mortality; Cardiovascular diseases mortality
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-019-1215-z

Cardiovascular disease (CVD) is the leading cause of death worldwide. Some studies have suggested anassociation between serum uric acid levels and cardiovascular mortality; however, the results have not been summarized in a meta-analysis.
A comprehensive search of all related studies until April 2018was performed in MEDLINE/PubMed and Scopus databases DerSimonianand Laird random-effects models were used to combine hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out.
Thirty-two studies containing forty-four arms with 1,134,073 participants reported association between uric acid and risk of CVD mortality were included in our analysis. Pooled results showed a significant positive association between uric acid levels and risk of CVD mortality (HR 1.45, 95% CI 1.33-1.58, I
 = 79%). Sub-group analysis showed this relationshipwasstronger in women compared to men. Moreover, there was a significant non-linear association between uric acid levels and the risk of CVD mortality (r = 0.0709, p = 0.001).
Our analysis indicates a positive dose-response association between SUA and CVD mortality risk.