Mononuclear phagocyte subpopulations in the mouse kidney

• Published in: American journal of physiology. Renal physiology Vol. 312; no. 4; p. F640
• Main Authors: George, James F, Lever, Jeremie M, Agarwal, Anupam
• Format: Journal Article
• Language: English
• Published: United States 01-04-2017
• Subjects: Acute Kidney Injury - immunology; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Animals; Biomarkers - metabolism; Cell Plasticity; Fibrosis; Humans; Inflammation Mediators - metabolism; Kidney - immunology; Kidney - metabolism; Kidney - pathology; Mice; Nephritis - immunology; Nephritis - metabolism; Nephritis - pathology; Phagocytes - classification; Phagocytes - immunology; Phagocytes - metabolism; Phagocytes - pathology; Phenotype; Receptors, Immunologic - metabolism; Signal Transduction; macrophages; acute kidney injury; ischemia-reperfusion; renal fibrosis; inflammation
• ISSN: 1522-1466
• DOI: 10.1152/ajprenal.00369.2016

Mononuclear phagocytes are the most common cells in the kidney associated with immunity and inflammation. Although the presence of these cells in the kidney has been known for decades, the study of mononuclear phagocytes in the context of kidney function and dysfunction is still at an early stage. The purpose of this review is to summarize the present knowledge regarding classification of these cells in the mouse kidney and to identify relevant questions that would further advance the field and potentially lead to new opportunities for treatment of acute kidney injury and other kidney diseases.