Factors associated with carotid Intima media thickness and carotid plaque score in community-dwelling and non-diabetic individuals

• Published in: BMC cardiovascular disorders Vol. 18; no. 1; p. 21
• Main Authors: Alizargar, Javad, Bai, Chyi-Huey
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06-02-2018; BioMed Central; BMC
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Atherosclerosis; Biomarkers - blood; Blood Pressure; Blood Urea Nitrogen; Carotid Arteries - diagnostic imaging; Carotid Arteries - pathology; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - epidemiology; Carotid Artery Diseases - pathology; Carotid Intima media thickness; China - epidemiology; Development and progression; Diabetes Mellitus - blood; Diabetes Mellitus - epidemiology; Female; Glycated Hemoglobin A - analysis; Glycosylated; Glycosylated hemoglobin; Hemoglobin A; Humans; Hypertension - epidemiology; Hypertension - physiopathology; Independent Living; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Obesity - epidemiology; Obesity - physiopathology; Odds Ratio; Plaque, Atherosclerotic; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Waist Circumference; Blood urea nitrogen; Carotid Intima media thickness; Hemoglobin A; Glycosylated; Atherosclerosis
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-018-0752-1

The carotid intima media thickness (cIMT) and carotid plaque score (cPS) are respective markers of early and late stage subclinical atherosclerosis. Relationships between some laboratory parameters and subclinical atherosclerosis are not yet clear in community dwelling individuals and non-diabetic subjects, so we try to elucidate these relationships and find a model to predict early and late stage subclinical atherosclerosis.
We examined relationships of the cIMT and cPS with different laboratory and demographic data of 331 subjects from a community-based prospective cohort study, using univariate and multivariate analyses.
In regression models and after multiple adjustments, only systolic blood pressure (SBP), age, glycated hemoglobin (HBA1c), and waist circumference (WC) were determinants of the cIMT, and only age, SBP, HBA1c, and blood urea nitrogen (BUN) were determinants of a cPS of > 2 in all individuals. Only HBA1c lost its association with regard to predicting the cIMT in non-diabetic subjects.
HBA1c at > 5.9% can determine early and late stage subclinical atherosclerosis in community dwelling individuals, but only late stage subclinical atherosclerosis in non-diabetic subjects.