The role of bacterial biofilm in persistent infections and control strategies

• Published in: International journal of oral science Vol. 3; no. 2; pp. 66 - 73
• Main Authors: Chen, Li, Wen, Yu‐mei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-04-2011; Springer Nature B.V; Key Laboratory of Medical Molecular Virology of Ministry of Education and Ministry of Public Health, Shanghai Medical School of Fudan University, Shanghai 200032, China; Nature Publishing Group
• Subjects: Adhesins, Bacterial - drug effects; Adhesins, Bacterial - physiology; Aminoacyltransferases - antagonists & inhibitors; Aminoacyltransferases - genetics; Animals; Antimicrobial Cationic Peptides - genetics; Antimicrobial Cationic Peptides - pharmacology; Bacteria; Bacterial Infections - microbiology; Bacterial Infections - surgery; Bacterial Proteins - antagonists & inhibitors; Bacterial Proteins - genetics; Biofilms - drug effects; Biofilms - growth & development; Chronic Disease; Cysteine Endopeptidases - genetics; Cysteine Proteinase Inhibitors - pharmacology; Dentistry; Humans; Inflammation - microbiology; Medicine; Oral and Maxillofacial Surgery; Orthopedics; Quorum Sensing - drug effects; Quorum Sensing - physiology; Review; Surgical Orthopedics; Wound Infection - microbiology; Wound Infection - surgery; 医疗器械; 持续性; 持续感染; 控制战略; 细菌感染; 细菌生物膜; 胞外多糖; 蛋白质组成; persistent infection; 3A remedies; biofilm
• ISSN: 1674-2818; 2049-3169
• DOI: 10.4248/IJOS11022

Bacterial biofilms can be viewed as a specific type of persistent bacterial infection. After initial invasion, microbes can attach to living and non-living surfaces, such as prosthetics and indwelling medical devices, and form a biofilm composed of extracellular polysaccharides, proteins, and other components. In hosts, bioffim formation may trigger drug resistance and inflammation, resulting in persistent infections. The clinical aspects of biofilm formation and leading strategies for hiofilm inhihitors will be discussed in this mini-review.