Association between IL1B gene and cervical cancer susceptibility in Chinese Uygur Population: A Case–Control study

• Published in: Molecular genetics & genomic medicine Vol. 7; no. 8; pp. e779 - n/a
• Main Authors: Wang, Li, Zhao, Wenhui, Hong, Jiajing, Niu, Fanglin, Li, Jing, Zhang, Shanshan, Jin, Tianbo
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-08-2019; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Aged; Alleles; Asian Continental Ancestry Group - genetics; Bans; Cancer; Case-Control Studies; Case–Control study; Cervical cancer; Cervix; Confidence intervals; Cytokines; Data collection; Deoxyribonucleic acid; DNA; Ethnic Groups - genetics; Female; Gene expression; Gene Expression Regulation, Neoplastic; Gene polymorphism; Genes; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Genotype; Haplotypes; Health risk assessment; Health risks; Hospitals; Humans; IL‐1B gene; Inflammation; Interleukin 1; Interleukin-1beta - genetics; Interleukins; Middle Aged; mRNA; Nucleotides; Odds Ratio; Original; Polymorphism; Polymorphism, Single Nucleotide; Population; Population studies; Prognosis; Sample size; Single-nucleotide polymorphism; Software; Studies; susceptibility; Thyroid cancer; Tumorigenesis; Tumors; Uterine Cervical Neoplasms - genetics; United States > US; China; IL-1B gene; susceptibility; single nucleotide polymorphism; cervical cancer; Case-Control study
• ISSN: 2324-9269; 2324-9269
• DOI: 10.1002/mgg3.779

Background
Interleukin‐1β (IL‐1B) has been recognized as a pro‐inflammatory cytokine and associated with tumorigenesis. We aimed to evaluate the contribution of IL‐1B polymorphisms to the susceptibility of cervical cancer in Chinese Uygur population.
Methods
Seven variants were genotyped by Agena MassARRAY platform in 267 cervical cancer patients and 302 healthy controls. Allelic, genotypic, and haplotypic association analyses adjusted for age were investigated using odds ratios (OR) and 95% confidence intervals (CI). GEPIA and UALCAN databases were used to evaluate expression and prognostic of IL‐1B gene in cervical cancer.
Results
Our result revealed IL‐1B rs1143627‐AA (OR = 1.98, p = 0.029) and rs16944‐GG (OR = 2.01, p = 0.025) was associated with an increased risk of cervical cancer. Besides, we also found two protective single nucleotide polymorphisms (SNPs) rs3136558 (OR = 0.63, p = 0.011) and rs1143630 (OR = 0.63, p = 0.019). Haplotype ″TGA″ in the block (rs1143630, rs1143627, and rs16944) significantly decreased the susceptibility of cervical cancer (OR = 0.53, p = 0.0007). IL‐1B mRNA level was up‐regulated in the cervical cancer patients, which was related with poor prognosis in silico.
Conclusions
For the first time, our results provide evidence on polymorphism of IL‐1B gene associated with cervical cancer risk in Chinese Uygur population.
Our study aimed to evaluate the contribution of IL‐1B gene to the susceptibility of cervical cancer in Chinese Uygur population. Our result revealed IL‐1B rs1143627 and rs16944 increased the risk of cervical cancer, while rs3136558 and rs1143630 reduced the risk. For the first time, our results provide evidence on polymorphism of IL‐1B gene associated with cervical cancer risk in Chinese Uygur population.