Haplotype Sharing Refines the Location of an Imprinted Quantitative Trait Locus With Major Effect on Muscle Mass to a 250-kb Chromosome Segment Containing the Porcine IGF2 Gene

• Published in: Genetics (Austin) Vol. 165; no. 1; pp. 277 - 285
• Main Authors: Nezer, Carine, Collette, Catherine, Moreau, Laurence, Brouwers, Benoit, Kim, Jong-Joo, Giuffra, Elisabetta, Buys, Nadine, Andersson, Leif, Georges, Michel
• Format: Journal Article Web Resource
• Language: English
• Published: United States Genetics Soc America 01-09-2003; Genetics Society of America; Genetics
• Subjects: Animals; Chromosomes; Gene loci; Genetic Linkage; Genetic Markers; Genetics; Genomic Imprinting; Haplotypes; Identification; Insulin-Like Growth Factor II - genetics; Life sciences; Muscles - metabolism; Muscular system; Médecine vétérinaire & santé animale; Quantitative Trait Loci; Sciences du vivant; Sus scrofa; Swine - genetics; Swine - metabolism; Veterinary medicine & animal health
• ISSN: 0016-6731; 1943-2631; 1943-2631
• DOI: 10.1093/genetics/165.1.277

We herein describe the fine mapping of an imprinted QTL with major effect on muscle mass that was previously assigned to distal SSC2p in the pig. The proposed approach exploits linkage disequilibrium in combination with QTL genotyping by marker-assisted segregation analysis. By identifying a haplotype shared by all "Q" chromosomes, we map the QTL to an approximately 250-kb chromosome segment containing INS and IGF2 as the only known paternally expressed genes. This considerably reinforces the candidacy of these genes, justifying their detailed analysis.