High Level of Plasma Remnant-like Particle Cholesterol May Predispose to Development of Hypertension in Normotensive Subjects

• Published in: American journal of hypertension Vol. 26; no. 6; pp. 793 - 798
• Main Authors: Kasahara, Akiko, Adachi, Hisashi, Hirai, Yuji, Enomoto, Mika, Fukami, Ako, Yoshikawa, Kuniko, Esaki, Eishi, Yokoi, Kanako, Ogata, Kinuka, Tsukagawa, Eri, Obuchi, Aya, Yoshimura, Ayako, Nakamura, Sachiko, Imaizumi, Tsutomu
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01-06-2013
• Subjects: Adult; Blood Pressure - physiology; Cholesterol - blood; Cross-Sectional Studies; Disease Progression; Disease Susceptibility - blood; Fasting; Female; Follow-Up Studies; Humans; Hypertension; Hypertension - blood; Hypertension - epidemiology; Incidence; Japan - epidemiology; Lipoproteins - blood; Male; Medical research; Middle Aged; Plasma; Postprandial Period; Retrospective Studies; Risk Factors; Triglycerides - blood; Japan; blood pressure; epidemiology; lipoprotein; hypertension; prospective study
• ISSN: 0895-7061; 1941-7225
• DOI: 10.1093/ajh/hpt011

BACKGROUND
Remnant-like lipoprotein particle cholesterol (RLP-C) is a highly atherogenic factor. RLP-C induces endothelial dysfunction and is associated with hyperinsulinemia. This study was designed to determine whether high plasma RLP-C levels predispose to the development of hypertension in subjects with normal blood pressure (BP).
METHODS
A total of 1,485 subjects aged >40 years in a Japanese Cohort of the Seven Countries Study received health examinations. We examined BP, anthropometric parameters, and blood chemistries, including fasting RLP-C levels. RLP-C levels were measured by an immune-separation method. We excluded from the analysis 676 subjects who had hypertension (BP ≥ 140/90mm Hg), or were on antihypertensive medication, and/or were on antihyperlipidemic medication at baseline. Ten years later, 681 subjects were re-examined.
RESULTS
Of 681 normotensive subjects at baseline, 303 subjects had developed hypertension 10 years later. Baseline RLP-C level was significantly higher (P < 0.01) in the subjects who developed hypertension than in those who remained normotensive (3.7±1.9 vs. 3.3±1.6mg/dl). Multivariable logistic regression analysis demonstrated that baseline RLP-C was a significant factor for incident hypertension after adjustments for homeostasis model assessment index and other hypertension-related factors (odds ratio = 1.05, 95% CI = 1.00-1.10; P = 0.04).
CONCLUSIONS
A high level of plasma RLP-C in normotensive subjects may predispose to the development of hypertension in a population of community-dwelling Japanese.