Nrf2 Participates in M2 Polarization by Trichinella spiralis to Alleviate TNBS-Induced Colitis in Mice

induced alternative activated macrophages (M2), leading to protect against Crohn's disease, known as Th1 -related inflammation, which enhances oxidative stress in the host. However, the relationship of oxidative stress and -mediated immune response is still unknown. In our study, we showed that...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 12; p. 698494
Main Authors:	Jin, Xuemin, Bai, Xue, Zhao, Ying, Dong, Zijian, Pang, Jianda, Liu, Mingyuan, Liu, Xiaolei
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 23-06-2021
Subjects:	Animals colitis Colitis - chemically induced Colitis - immunology Disease Models, Animal Female Immunology macrophage Macrophages - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL NF-E2-Related Factor 2 - immunology Nrf2 Th2 TNBS Trichinella spiralis Trichinella spiralis - immunology Trichinellosis - immunology Trinitrobenzenesulfonic Acid - toxicity macrophage Trichinella spiralis colitis TNBS Nrf2 Th2
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Summary:	induced alternative activated macrophages (M2), leading to protect against Crohn's disease, known as Th1 -related inflammation, which enhances oxidative stress in the host. However, the relationship of oxidative stress and -mediated immune response is still unknown. In our study, we showed that nuclear factor erythroid 2-related factor-2 (Nrf2), a key transcription factor in antioxidant, participated in M2 polarization induced by muscle larval excretory/secretory (ES) products . ES -treated M2 were injected intravenously after TNBS challenge and we demonstrated that ES-M could alleviate the severity of the colitis in mice. Adoptive transfer of ES -treated M2 decreased the level of IFN-γ and increased the levels of IL-4 and IL-10 . However, the capacity of ES -treated Nrf2 KO macrophages to treat colitis was dramatically impaired. ES -treated Nrf2 KO macrophages was insufficient to result in the elevated levels of IL-4 and IL-10. These findings indicate that Nrf2 was required for M2 polarization induced by ES to alleviate colitis in mice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology Reviewed by: Yixin Lu, Northeast Agricultural University, China; Natasa Ilic, Institute for the Application of Nuclear Energy (INEP), Serbia These authors have contributed equally to this work Edited by: Allen D. Smith, United States Department of Agriculture, United States
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2021.698494