Intracerebroventricular injection of kynurenic acid attenuates corticotrophin-releasing hormone-augmented stress responses in neonatal chicks

• Published in: Neuroscience Vol. 220; pp. 142 - 148
• Main Authors: Yoshida, J, Tomonaga, S, Ogino, Y, Nagasawa, M, Kurata, K, Furuse, M
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 18-09-2012; Elsevier
• Subjects: Animals; Animals, Newborn; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Chickens; Corticotropin-Releasing Hormone - metabolism; Excitatory Amino Acid Antagonists - administration & dosage; Fundamental and applied biological sciences. Psychology; Injections, Intraventricular; intracerebroventricular injection; kynurenic acid; Kynurenic Acid - administration & dosage; l-tryptophan; Male; neonatal chick; Neurology; Social Isolation; social separation stress; Stress, Psychological - metabolism; Tryptophan - pharmacology; Vertebrates: nervous system and sense organs; corticotrophin-releasing hormone; KYN; KYNA; intracerebroventricular injection; l-tryptophan; kynurenine; neonatal chick; serotonin; TRP; social separation stress; CRH; NMDA; N-methyl- d -aspartate; 5-HT; kynurenic acid; L-tryptophan
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.06.041

Highlights ► Kynurenic acid seemed to have a stronger sedative effect than tryptophan under social isolation stress. ► Intracerebroventricular injection of kynurenic acid induced a strong sedative effect under stress. ► Kynurenic acid is a likely candidate for the sedative and hypnotic effects of tryptophan under acutely stressful conditions.