Insertion deletion polymorphism of the bradykinin type 2 receptor gene influence diastolic blood pressure

• Published in: Journal of human hypertension Vol. 23; no. 8; pp. 553 - 555
• Main Authors: Freitas, S R, Pereira, A C, Floriano, M S, Mill, J G, Krieger, J E
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-08-2009; Nature Publishing Group
• Subjects: Adult; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood pressure; Blood Pressure - genetics; Bradykinin; Brazil; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Cross-Sectional Studies; Diastole - genetics; Epidemiology; Female; Gene deletion; Gene polymorphism; Genetic aspects; Health Administration; Humans; Hypertension; Hypertension - genetics; INDEL Mutation; Insertion; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Neural receptors; Physiological aspects; Polymorphism, Genetic - genetics; Predictive Value of Tests; Public Health; Receptor, Bradykinin B2 - genetics; research-letter; Risk Factors; Urban Population; Brazil; Hypertension; Diastolic pressure; Vasodilator agent; Bradykinin; Peptide hormone; Deletion; Cardiovascular disease; Arterial pressure; Blood pressure; Polymorphism
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/jhh.2009.23

The contribution of kinins to the beneficial effects in cardiovascular risk reductions remains unclear. In this context, the present study examined whether the +9 bp/-9 bp polymorphism in bradykinin type 2 receptor gene, predicts hypertension risk in a large urban Brazilian population. Our finding indicated that the -9 bp allele may contribute to hypertension because of increased diastolic pressure.