Campylobacter jejuni bacteremia and Helicobacter pylori in a patient with X-linked agammaglobulinemia

• Published in: European journal of clinical microbiology & infectious diseases Vol. 29; no. 11; pp. 1315 - 1319
• Main Authors: van den Bruele, T., Mourad-Baars, P. E. C., Claas, E. C. J., van der Plas, R. N., Kuijper, E. J., Bredius, R. G. M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01-11-2010; Springer; Springer Nature B.V
• Subjects: Adolescent; Agammaglobulinemia - complications; Anti-Bacterial Agents - therapeutic use; Bacteremia - complications; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Bacterial sepsis; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Campylobacter Infections - complications; Campylobacter Infections - drug therapy; Campylobacter Infections - microbiology; Campylobacter jejuni; Campylobacter jejuni - pathogenicity; Doxycycline - therapeutic use; Drug Resistance, Bacterial - genetics; Erythromycin - therapeutic use; Genetic Diseases, X-Linked - complications; Helicobacter Infections - complications; Helicobacter Infections - drug therapy; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - pathogenicity; Human bacterial diseases; Humans; Immunocompromised Host; Infectious diseases; Internal Medicine; Malabsorption Syndromes - complications; Male; Medical Microbiology; Medical sciences; Mutation; Recurrence; Review; Thienamycins - therapeutic use; Blood Culture Bottle; Meropenem; Standard Deviation Score; Erythromycin; Common Variable Immunodeficiency; Human; Immunopathology; Spirillales; Microbiology; Campylobacteraceae; Agammaglobulinemia; Spirillaceae; Bacteremia; Campylobacter jejuni; Infection; Helicobacter pylori; Bacteriosis; Bacteria
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-010-0999-7

We describe a 15-year-old patient with X-linked agammaglobulinemia who developed malabsorption and bacteremia due to infection of
Helicobacter pylori
and
Campylobacter jejuni
. The
Campylobacter
bacteremia was only recognized after subculturing of blood culture bottles that failed to signal in the automated system. After 2 weeks of treatment with meropenem and erythromycin for 4 weeks, the patient developed a relapse of bacteremia 10 months later with a high level erythromycin resistant
C. jejuni
. Sequencing revealed an A2058C mutation in the 23 S rRNA gene associated with this resistance. Treatment with doxycycline for 4 weeks finally resulted in complete eradication. This case report illustrates the importance for physicians to use adapted culture methods and adequate prolonged therapy in patients with an immunodeficiency. A summary of published case reports and series of patients with hypogammaglobulinemia or agammaglobulinemia with
Campylobacter
or
Helicobacter
bacteremia is given.