Simple and efficient synthesis of 2,7-difunctionalized-1,8-naphthyridines

• Published in: Molecules (Basel, Switzerland) Vol. 10; no. 8; pp. 929 - 936
• Main Authors: Goswami, Shyamaprosad, Mukherjee, Reshmi, Mukherjee, Rakhi, Jana, Subrata, Maity, Annada C, Adak, Avijit Kumar
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31-08-2005; MDPI
• Subjects: 7-diamino-1; 7-difunctionalized-1; 8- naphthyridine; 8-naphthyridines; Naphthyridines; Naphthyridines - chemical synthesis; Naphthyridines - chemistry; Polyethylene Glycols - chemistry; Reagents; Scholarships & fellowships; Temperature; India
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/10080929

The syntheses in good yields of some new difunctionalized 1,8-naphthyridines 4, 6, 8 and 9 and a novel triethylene glycol ether-linked dinaphthyridine, 10a, along with the mononaphthyridine-linked ether alcohol 10b are described. An improved and milder method for the synthesis of 2,7-diamino-1,8-naphthyridine (14) is also reported.