Comparison of Premortem Magnetic Resonance Imaging and Postmortem Autopsy Findings of a Cortical Microinfarct

• Published in: Journal of stroke and cerebrovascular diseases Vol. 27; no. 10; pp. 2623 - 2626
• Main Authors: Ishikawa, Hidehiro, Ii, Yuichiro, Niwa, Atsushi, Shindo, Akihiro, Ito, Ai, Matsuura, Keita, Sasaki, Ryogen, Uno, Kenichiro, Maeda, Masayuki, Tomimoto, Hidekazu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-10-2018
• Subjects: Aged, 80 and over; angiopathy; Autopsy; Biopsy; cerebral amyloid; Cerebral Amyloid Angiopathy - diagnostic imaging; Cerebral Amyloid Angiopathy - pathology; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cerebral Infarction - diagnostic imaging; Cerebral Infarction - pathology; cerebrovascular disease; dementia; double inversion recovery; Fatal Outcome; Female; histopathology; Humans; Iba1; Magnetic Resonance Imaging; Microinfarcts; Predictive Value of Tests; premortem MRI; small vessel disease; angiopathy; small vessel disease; cerebral amyloid; cerebrovascular disease; double inversion recovery; histopathology; dementia; Iba1; Microinfarcts; premortem MRI
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2018.05.037

An 85-year-old woman diagnosed with amyotrophic lateral sclerosis died of pneumonia and was autopsied. Magnetic resonance imaging (MRI) performed 16 days before death revealed an intracortical high-intensity lesion in her right temporal cortex on three-dimensional (3D)-double inversion recovery (DIR) and 3D-fluid-attenuated inversion recovery (FLAIR) images. Histopathological examination indicated a cortical microinfarct (CMI) juxtaposed to cerebral amyloid angiopathy. Recently, in vivo detection of CMIs using 3D-DIR and 3D-FLAIR on 3-tesla MRI has been reported, and postmortem MRI study confirmed the presence of CMIs. This is the first case study to compare CMI findings detected upon premortem MRI to the CMI itself discovered upon postmortem neuropathological examination.