Protective effects of a standardized extract of Iris germanica on pancreas and liver in streptozotocin-induced diabetic rats

• Published in: Research in pharmaceutical sciences Vol. 16; no. 1; pp. 71 - 78
• Main Authors: Mahdinezhad, Mohammad Reza, Hooshmand, Sara, Soukhtanloo, Mohammad, Jamshidi, Shirin Taraz, Ehtiati, Sajad, Ghorbani, Ahmad
• Format: Journal Article
• Language: English
• Published: Iran Medknow Publications and Media Pvt. Ltd 01-02-2021; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Care and treatment; Complications and side effects; Diabetes; diabetes; glucose; iris germanica; lipids; oxidative stress; Health aspects; Iris (Plant); Liver diseases; Materia medica, Vegetable; Original; Pancreatic diseases; Plant extracts; Streptozocin; Iran; Oxidative stress; Lipids; Diabetes; Glucose; Iris germanica
• ISSN: 1735-5362; 1735-9414
• DOI: 10.4103/1735-5362.305190

Previous studies have shown the antioxidant, anti-inflammatory, immunomodulatory, and hypolipidemic activities of
. The aim of the present study was to evaluate the protective effects of hydroalcoholic extract of
rhizomes on streptozotocin-induced diabetic rats.
Twenty-four male Wistar rats were randomly assigned into four groups including a normal control group, diabetic control group, diabetic groups treated for 4 weeks with 100 and 200 mg/kg/day of the
extract (IGE).
Induction of diabetes significantly decreased the body weight gain and considerably increased the serum levels of glucose, triglyceride, blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Diabetes also diminished the antioxidant capacity of the liver (decrease of thiol groups) and significantly degenerated pancreatic islands. The IGE at both doses of 100 and 200 mg/kg significantly reduced the levels of glucose, triglyceride, AST, ALT, and ALP. Moreover, IGE increased the total antioxidant capacity of the liver and ameliorated pancreatic island morphology. The extract had no significant effect on body weight and BUN level.
These findings suggest that
rhizomes inhibits the progression of hyperglycemia and hypertriglyceridemia and has protective effects against diabetes-induced injury of the liver and pancreas. Therefore, this plant has the potential to be used as a natural product for controlling diabetes.