Relationship between neuropsychological behavior and brain white matter in first-episode psychosis

We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically...

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Bibliographic Details
Published in:	Schizophrenia research Vol. 208; pp. 49 - 54
Main Authors:	Faria, Andreia V., Crawford, Jeffrey, Ye, Chenfei, Hsu, Johnny, Kenkare, Anshel, Schretlen, David, Sawa, Akira
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-06-2019
Subjects:	Cognition DTI First-episode psychosis MRI Schizophrenia DTI Schizophrenia First-episode psychosis Cognition MRI
Online Access:	Get full text
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Summary:	We addressed the relationship between white matter architecture, represented by MRI fractional anisotropy (FA), and cognition in individuals with first-episode psychosis (FEP) by applying for a new methodology that allows whole brain parcellation of core and peripheral white matter in a biologically meaningful fashion. Regionally specific correlations were found in FEP between three specific domains of cognition (processing speed, attention/working memory, and executive functioning) and FA at the deep (cerebral peduncles, sagittal striatum, uncinate, internal/external capsule, cingulum) and peripheral white matter (adjacent to inferior temporal, angular, supramarginal, insula, occipital, rectus gyrus).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 JH: contributed analysis tools AK: edited the paper, contributed discussion CY: contributed analysis tools AS: conceived the analysis; wrote the paper Contributors JC: collected data; contributed data AVF: conceived and designed the analysis; contributed analysis tools, performed the analysis; wrote the paper DS: collected data; contributed data
ISSN:	0920-9964 1573-2509
DOI:	10.1016/j.schres.2019.04.010