Arterial Spin Labeling MRI: A step forward in non-invasive delineation of focal cortical dysplasia in children

• Published in: Epilepsy research Vol. 108; no. 10; pp. 1932 - 1939
• Main Authors: Blauwblomme, Thomas, Boddaert, Nathalie, Chémaly, Nicole, Chiron, Catherine, Pages, Mélanie, Varlet, Pascale, Bourgeois, Marie, Bahi-Buisson, Nadia, Kaminska, Anna, Grevent, David, Brunelle, Francis, Sainte-Rose, Christian, Archambaud, Frédérique, Nabbout, Rima
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01-12-2014; Elsevier
• Subjects: Adolescent; Antigens, CD34 - metabolism; Arterial Spin Labeling; Biological and medical sciences; Brain - diagnostic imaging; Brain - pathology; Brain - physiopathology; Cerebrovascular Circulation - physiology; Child; Child, Preschool; Epilepsy surgery; FDG-PET; Female; Fluorodeoxyglucose F18; Focal cortical dysplasia; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Magnetic Resonance Imaging - methods; Male; Malformations of Cortical Development - diagnosis; Malformations of Cortical Development - diagnostic imaging; Malformations of Cortical Development - pathology; Malformations of Cortical Development - physiopathology; Medical sciences; Microvessels - pathology; Microvessels - physiopathology; Nervous system (semeiology, syndromes); Neurology; Radionuclide Imaging; Radiopharmaceuticals; Retrospective Studies; Spin Labels; FDG-PET; FCD; CBF; single photon emission computed tomography; PD-read out; Epilepsy surgery; SPECT; post-data read out; focal cortical dysplasia; Arterial Spin Labeling; cerebral blood flow; ASL; positron emission tomography; PET; Focal cortical dysplasia; Human; Nervous system diseases; Dysplasia; 2-deoxy-2-fluoroglucose; Epilepsy; Nuclear magnetic resonance imaging; Cerebral disorder; Surgery; Central nervous system disease; Non invasive method; Spin labeling; Child; Positron emission tomography
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2014.09.029

Highlights • Morphological MRI fails to identify FCD in up to 40% of the cases. • We investigate Arterial Spin Labeling MRI in nine children with FCD. • We show decreased cerebral blood flow on ASL MRI in FCD. • It is colocalized with PET scan and histological abnormality. • ASL MRI may help increase diagnostic accuracy of MRI in pediatric FCD.