Sesamum indicum diet prevents hyperlipidemia in experimental rats

• Published in: Food chemistry. Molecular sciences Vol. 4; p. 100092
• Main Authors: Adeyanju, Muinat M., Saheed, Idris A., Oyelekan, Oluwaseun I., Dele-Osibanjo, Taiwo A., Adelegan, Ayodeji A., Raimi, Adekunle J., Olalekan, Samuel O., Alabi, Olugbenga S., Alli, Khadijat M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30-07-2022; Elsevier
• Subjects: Cardiovascular disease; Cholesterol; HMG-CoA reductase; Hyperlipidemia; Sesamum indicum; Hyperlipidemia; HDL-PL; HFD; HMG-CoA; Cardiovascular disease; Sesamum indicum; HDL-TG; NCD; Cholesterol; TC; CVD; HDL-C; HDL; CPT1; LDL; HMG-CoA reductase; SI; VLDL; UCP2; AMPK; CD36; SREBP1; PPAR-α; LDL, low density lipoprotein; NCD, non-communicable disease; UCP2, uncoupling protein 2; CVD, cardiovascular disease; PPAR-α, peroxisome proliferator-activated receptor-α; HDL, high density lipoprotein; SI, Sesamum indicum; CPT1, carnitinepalmitoyltransferase-1; HDL-C, high-density lipoprotein-cholesterol; SREBP1, sterol regulatory element binding protein-1; AMPK, adenosine monophosphate-activated protein kinase; VLDL, very low-density lipoprotein; HDL-PL, high-density lipoprotein-phospholipid; CD36, cluster of differentiation 36; HDL-TG, high-density lipoprotein-triglyceride; HFD, high fat diet; HMG-CoA, 3-Hydroxy-3-methyl glutaryl-coenzyme A; TC, total cholesterol
• ISSN: 2666-5662; 2666-5662
• DOI: 10.1016/j.fochms.2022.100092

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•Sesamum indicum administration reverses the dyslipidemia in hyperlipidemic rats.•Hypolipidemic potency of Sesamum indicum is due to inhibition of HMG-CoA reductase activity.•Our findings lend credence to the use of Sesamum indicum as a therapeutic remedy in traditional medicine for hyperlipidemia and associated morbidities.
Cardiovascular diseases and metabolic complications caused by hyperlipidemia are the leading cause of death globally. In this study, the hypolipidemic potency of Sesamum indicum (SI) seeds was investigated. Of the thirty-five (35) male rats used in the study, five (5) were randomly selected for baseline measurements and thirty (30) were fed high fat diet (HFD) for four (4) weeks before random assignment into three (3) groups. The experimental group was treated with 50% SI seed, the positive control group was given a hypolipidemic drug, atorvastatin (5 mg/kg/day) while the untreated group served as the negative control. With SI administration, the dyslipidemia induced by the HFD consumption in the plasma and the investigated body organs was reversed to a comparable degree with that of atorvastatin treatment. Taken together, this study demonstrates the hypolipidemic potency of SI in ameliorating hyperlipidemia and its associated complications, facilitated by the inhibition of HMG-CoA reductase activity.