A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy

• Published in: Advanced science Vol. 9; no. 31; pp. e2202332 - n/a
• Main Authors: Wang, Man, Chang, Mengyu, Zheng, Pan, Sun, Qianqian, Wang, Guangqiang, Lin, Jun, Li, Chunxia
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01-11-2022; John Wiley and Sons Inc; Wiley
• Subjects: Adenosine triphosphate; Antibodies; Cancer therapies; cascade reactor; Cell Line, Tumor; Fever; Glucose; Glucose Oxidase - metabolism; Glucose Oxidase - therapeutic use; Heat; Heat shock proteins; Hyperthermia; immune system activation; Immunotherapy; Lasers; mild photothermal therapy; nanozymes; Phototherapy; Photothermal Therapy; Spectrum analysis; starvation therapy; synergistic therapy; Transmission electron microscopy; Tumors; nanozymes; cascade reactor; synergistic therapy; mild photothermal therapy; immune system activation; starvation therapy
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202202332

Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting immune responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal therapy (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic “cold” tumor microenvironment. Further, to amplify the thermal sensitivity of tumor cells, glucose oxidase (GOx) is introduced to suppress the production of heat shock proteins, thereby promoting mild photothermal therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate tumor hypoxia, significantly improving the GOx activity. As a result, the combination of AuPtAg‐GOx with self‐augmented photothermal ability and PD‐L1 antibody can further escalate the antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, mild PTT, and immunotherapy cascade enhancement therapy strategy can be a favorable tool to effectively kill cancer cells.
A cascade promoted AuPtAg‐glucose oxidase (GOx) nanomodulator is designed for synergistic starvation/photothermal/immunotherapy. The GOx‐mediated starvation therapy inhibits heat shock protein production for enhanced AuPtAg mediated mild photothermal therapy, which would sequentially activate the systemic immune response, prompting the tumor microenvironment to become “hot.” Therefore, AuPtAg‐GOx combined with ɑ‐PD‐1 ligand 1 could obviously inhibit tumor growth.