Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP,...

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Bibliographic Details
Published in:Frontiers in chemistry Vol. 5; p. 89
Main Authors: Qian, Yun, Han, Qixin, Chen, Wei, Song, Jialin, Zhao, Xiaotian, Ouyang, Yuanming, Yuan, Weien, Fan, Cunyi
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 31-10-2017
Subjects:
cell differentiation
Chemistry
growth factors
musculoskeletal regeneration
platelet-rich plasma
stem cells
stem cells
cell differentiation
musculoskeletal regeneration
growth factors
platelet-rich plasma
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Summary:Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. These GFs can stimulate proliferation and differentiation of different stem cells in injury models. Therefore, combination of both agents receives wide expectations in regenerative medicine, especially in bone, cartilage and tendon repair. In this review, we thoroughly discussed the interaction and underlying mechanisms of PRP derived GFs with stem cells, and assessed their functions in cell differentiation for musculoskeletal regeneration.
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Reviewed by: Francesco Grassi, Istituto Ortopedico Rizzoli (IRCCS), Italy; Dharmendra Kumar Yadav, All India Institute of Medical Sciences Jodhpur, India
This article was submitted to Medicinal and Pharmaceutical Chemistry, a section of the journal Frontiers in Chemistry
These authors have contributed equally to this work.
Edited by: Simona Rapposelli, University of Pisa, Italy
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2017.00089