Contrasting female-male mortality ratios after routine vaccinations with pentavalent vaccine versus measles and yellow fever vaccine. A cohort study from urban Guinea-Bissau

Highlights • Vaccines have sex-differential non-specific effects affecting mortality. • The transition from DTP to measles vaccine lowers female/male mortality ratio. • Penta recently replaced DTP and yellow fever vaccine is now given with measles vaccine. • Pentavalent vaccine is associated with 73...

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Bibliographic Details
Published in:	Vaccine Vol. 34; no. 38; pp. 4551 - 4557
Main Authors:	Fisker, Ane B, Biering-Sørensen, Sofie, Lund, Najaaraq, Djana, Queba, Rodrigues, Amabelia, Martins, Cesario L, Benn, Christine S
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 31-08-2016 Elsevier Limited
Subjects:	Age Allergy and Immunology Birth weight Child Child Mortality Child, Preschool Children & youth Diphtheria-Tetanus-Pertussis Vaccine - adverse effects Diphtheria-Tetanus-Pertussis Vaccine - therapeutic use Female Females Fever Guinea-Bissau - epidemiology Haemophilus Vaccines - adverse effects Haemophilus Vaccines - therapeutic use Hepatitis B Vaccines - adverse effects Hepatitis B Vaccines - therapeutic use Humans Hypotheses Immunization Immunization Programs Infant Influenza Low income groups Male Measles Measles vaccine Measles Vaccine - adverse effects Measles Vaccine - therapeutic use Mortality Non-specific/heterologous effects of vaccines Pentavalent vaccine Proportional Hazards Models Public health Random Allocation Ratios Sex Factors Sex Ratio Sex-difference Survival Analysis Vaccines Vector-borne diseases Vitamin A Yellow Fever Vaccine - adverse effects Yellow Fever Vaccine - therapeutic use Guinea-Bissau Non-specific/heterologous effects of vaccines Sex-difference Measles vaccine Pentavalent vaccine Mortality
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Summary:	Highlights • Vaccines have sex-differential non-specific effects affecting mortality. • The transition from DTP to measles vaccine lowers female/male mortality ratio. • Penta recently replaced DTP and yellow fever vaccine is now given with measles vaccine. • Pentavalent vaccine is associated with 73% higher female than male mortality. • Yellow fever and measles vaccine are associated with lower female mortality.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.07.034