Feasibility of Beans/Bran Enriching Nutritional Eating For Intestinal Health & Cancer Including Activity for Longevity: A Pilot Trial to Improve Healthy Lifestyles among Individuals at High Risk for Colorectal Cancer

• Published in: Integrative cancer therapies Vol. 19; p. 1534735420967101
• Main Authors: Leach, Heather J., Baxter, Bridget A., Beale, Melanie N., Smith, Hillary V., Rao, Sangeeta, Hibbs-Shipp, Sarah, Ryan, Elizabeth P.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 2020; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Adult; Beans; Cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - prevention & control; Dietary Fiber; Dietary supplements; Feasibility Studies; Healthy Lifestyle; Humans; Intestine; Longevity; Physical activity; Pilot Projects; Rice; cancer prevention; rice bran; colorectal; navy bean; adenomatous polyp
• ISSN: 1534-7354; 1552-695X
• DOI: 10.1177/1534735420967101

Purpose:
Examine the feasibility and preliminary effects of a lifestyle intervention of rice bran plus navy bean supplementation, and physical activity (PA) education on intake of fiber and whole grains, and PA levels.
Design:
Randomized-controlled, single-blinded.
Setting:
Academic institution and free-living.
Subjects:
Adults >18 years, with ≥1 adenomatous polyp removed within 3 years.
Intervention:
Participants received powder and pre-prepared meals and snacks that contained either rice bran (30 g/day) plus navy bean (30 g/day), or Fibersol-2® (10 g/day), for 12-weeks. All participants received a 1-hour (PA) education session.
Measures:
Feasibility was assessed by recruitment and retention rates, and compliance to the study foods and procedures. Three-day food logs were analyzed using Nutritionist Pro™ to estimate fiber intake, and the Automated Self-Administered 24-hour (ASA24®) Dietary Assessment Tool calculated Healthy Eating Index (HEI) whole grain and total scores. PA was measured using an ActivPAL™ accelerometer.
Analysis:
Continuous data were summarized as median, range, and percent change from baseline to post-intervention.
Results:
N = 20 (86.9%) completed the intervention. Compliance was 92% in the rice bran plus navy bean versus 89% in Fibersol-2®. Navy bean consumption increased from 2 g/day to 30 g/day, and rice bran from 0 g/day to 30 g/day. Fiber intake (g/day) increased by 73% versus 82%, HEI whole grain improved by 270% versus 37%, and HEI total improved by 10% versus 9.1% in rice bran plus navy bean and Fibersol-2®, respectively. Total PA (MET-hours/day) showed minimal change for intervention (+0.04%) and control (+4%).
Conclusion:
Findings merit a larger trial of rice bran plus navy bean and PA to evaluate efficacy for dietary and cancer prevention-related outcomes.