Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives

• Published in: BioMed research international Vol. 2014; no. 2014; pp. 1 - 8
• Main Authors: da Silva, Ivanildo Mangueira, da Silva Filho, João, Santiago, Priscila Brandão Gomes da Silva, do Egito, Micalyne Soares, de Souza, Carlos André, Gouveia, Frederico Leite, Ximenes, Rafael Matos, de Sena, Kêsia Xisto da Fonseca Ribeiro, de Faria, Antonio Rodolfo, Brondani, Dalci José, de Albuquerque, Julianna Ferreira Cavalcanti
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01-01-2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acids; Anti-infective agents; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - chemical synthesis; Antibiotics; Antimicrobial agents; Bacteria; Bacterial Physiological Phenomena - drug effects; Cancer; Cell Survival - drug effects; Chemistry; Dosage and administration; Dose-Response Relationship, Drug; Drug resistance in microorganisms; Gram-positive bacteria; Lethal Dose 50; Methods; Pharmaceutical industry; Pharmaceutical sciences; Studies; Thiazolidinediones; Thiazolidines - administration & dosage; Thiazolidines - chemical synthesis
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2014/316082

Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gram-negative, and alcohol acid resistant bacteria and yeast. The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 µg/mL.