Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis : A Cross-Sectional Study in a Mexican Population

• Published in: BioMed research international Vol. 2014; no. 2014; pp. 1 - 6
• Main Authors: Martínez-García, Erika Aurora, Martín-Márquez, Beatriz Teresita, Gómez-Bañuelos, Eduardo, Figueroa-Sanchez, Mauricio, Nuñez-Atahualpa, Lourdes, Rocha-Muñoz, Alberto Daniel, Sánchez-Hernández, Pedro Ernesto, Navarro-Hernandez, Rosa Elena, Madrigal-Ruiz, Perla Monserrat, Saldaña-Millan, Adan Alberto, Duran-Barragan, Sergio, Gonzalez-Lopez, Laura, Gamez-Nava, Jorge Ivan, Vázquez-Del Mercado, Mónica
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01-01-2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Adult; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - complications; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - complications; Cardiovascular disease; Carotid Intima-Media Thickness; CD36 Antigens - blood; Cell Membrane - metabolism; Cholesterol; Complications and side effects; Cross-Sectional Studies; Development and progression; Drug therapy; Female; Humans; Interleukin-6 - blood; Male; Membrane proteins; Mexico; Middle Aged; Monocytes; Monocytes - metabolism; Pathogenesis; Rheumatoid arthritis; Risk factors; Studies; Tumor Necrosis Factor-alpha - blood; Mexico
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2014/736786

Patients with rheumatoid arthritis (RA) have a higher risk for atherosclerosis. There is no clinical information about scavenger receptor CD36 and the development of subclinical atherosclerosis in patients with RA. The aim of this study was to evaluate the association between membrane expression of CD36 in peripheral blood mononuclear cells (PBMC) and carotid intima-media thickness (cIMT) in patients with RA. Methods. We included 67 patients with RA from the Rheumatology Department of Hospital Civil “Dr. Juan I. Menchaca,” Guadalajara, Jalisco, Mexico. We evaluated the cIMT, considering subclinical atherosclerosis when >0.6 mm. Since our main objective was to associate the membrane expression of CD36 with subclinical atherosclerosis, other molecules related with cardiovascular risk such as ox-LDL, IL-6, and TNFα were tested. Results. We found low CD36 membrane expression in PBMC from RA patients with subclinical atherosclerosis (P<0.001). CD36 mean fluorescence intensity had negative correlations with cIMT (r = −0.578, P<0.001), ox-LDL (r = −0.427, P = 0.05), TNFα (r = −0.729, P<0.001), and IL-6 (r = −0.822, P<0.001). Conclusion. RA patients with subclinical atherosclerosis showed low membrane expression of CD36 in PBMC and increased serum proinflammatory cytokines. Further studies are needed to clarify the regulation of CD36 in RA.