Role of environmental pollutants in liver physiology: special references to peoples living in the oil drilling sites of Assam

• Published in: PloS one Vol. 10; no. 4; p. e0123370
• Main Authors: Dey, Tapan, Gogoi, Kabita, Unni, Balagopalan, Bharadwaz, Moonmee, Kalita, Munmi, Ozah, Dibyajyoti, Kalita, Manoj, Kalita, Jatin, Baruah, Pranab Kumar, Bora, Thaneswar
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13-04-2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Air Pollutants - chemistry; Air pollution; Air pollution measurements; Alanine; Alanine transaminase; Alanine Transaminase - blood; Alkaline phosphatase; Alkaline Phosphatase - blood; Anorexia - etiology; Aspartate Aminotransferases - blood; Aspartate transaminase; Asthma; Biotechnology; Blood & organ donations; Chronic obstructive pulmonary disease; Councils; Drilling; Environmental cleanup; Environmental Exposure; Epidemiology; Exposure; Female; Gaseous pollutants; Humans; India; Industrial research; Liver; Liver - drug effects; Liver diseases; Male; Middle Aged; Mortality; Nausea - etiology; Nitrogen dioxide; Nitrogen Dioxide - chemistry; Oil; Oil and Gas Fields; Particulate emissions; Particulate matter; Particulate Matter - chemistry; PCB; Physiology; Pollutants; Polychlorinated biphenyls; Populations; Probability; Public health; Regression analysis; Regression models; Respiratory diseases; Science; Spectrophotometers; Spectrophotometry; Studies; Sulfur; Sulfur dioxide; Sulfur Dioxide - chemistry; Transaminase; Weight Loss; India
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0123370

The populations residing near polluted sites are more prone to various types of diseases. The important causes of air pollution are the suspended particulate matter, respirable suspended particulate matter, sulfur dioxide and nitrogen dioxide. As limited information is available enumerating the effect of these pollutants on liver physiology of the population living near the polluted sites; in the present study, we tried to investigate their effect on liver of the population residing near the oil drilling sites since birth. In this study, a randomly selected 105 subjects (46 subjects from oil drilling site and 61 subjects from control site) aged above 30 years were taken under consideration. The particulate matter as well as the gaseous pollutants, sulfur dioxide and nitrogen dioxide, were analyzed through a respirable dust sampler. The level of alkaline phosphatase, alanine transaminase and aspartate transaminase enzymes in serum were measured by spectrophotometer. The generalized regression model studies suggests a higher concentration of respirable suspended particulate matter, suspended particulate matter and nitrogen dioxide lowers the alkaline phosphatase level (p<0.0001) by 3.5 times (95% CI 3.1-3.9), 1.5 times (95% CI 1.4-1.6) and 12 times (95% CI 10.74-13.804), respectively in the exposed group. The higher concentration of respirable suspended particulate matter and nitrogen dioxide in air was associated with increase in alanine transaminase level (p<0.0001) by 0.8 times (95% CI 0.589-1.049) and by 2.8 times (95% CI 2.067-3.681) respectively in the exposed group. The increase in nitrogen dioxide level was also associated with increase in aspartate transaminase level (p<0.0001) by 2.5 times (95% CI 1.862-3.313) in the exposed group as compared to control group. Thus, the study reveals that long-term exposure to the environmental pollutants may lead to liver abnormality or injury of populations living in polluted sites.