Rate of Intensive Care Unit admission and outcomes among patients with coronavirus: A systematic review and Meta-analysis
The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus. A...
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Published in: | PloS one Vol. 15; no. 7; p. e0235653 |
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Main Authors: | , , , |
Format: | Journal Article |
Language: | English |
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Public Library of Science
10-07-2020
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Abstract | The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.
A comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded.
A total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants).
The Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients.
This Systematic review and Meta-Analysis was registered in Prospero international prospective register of systemic reviews (CRD42020177095) on April 9/2020. |
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AbstractList | The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.BACKGROUNDThe rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.A comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded.METHODSA comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded.A total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants).RESULTA total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants).The Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients.CONCLUSIONThe Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients.This Systematic review and Meta-Analysis was registered in Prospero international prospective register of systemic reviews (CRD42020177095) on April 9/2020.REGISTRATIONThis Systematic review and Meta-Analysis was registered in Prospero international prospective register of systemic reviews (CRD42020177095) on April 9/2020. Background The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus. Methods A comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded Result A total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants). Conclusion The Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients. Registration This Systematic review and Meta-Analysis was registered in Prospero international prospective register of systemic reviews (CRD42020177095) on April 9/2020. The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus. A comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded. A total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants). The Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients. This Systematic review and Meta-Analysis was registered in Prospero international prospective register of systemic reviews (CRD42020177095) on April 9/2020. BackgroundThe rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.MethodsA comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded.ResultA total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants).ConclusionThe Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients.RegistrationThis Systematic review and Meta-Analysis was registered in Prospero international prospective register of systemic reviews (CRD42020177095) on April 9/2020. Background The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus. Methods A comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded Result A total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants). Conclusion The Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients. Registration This Systematic review and Meta-Analysis was registered in Prospero international prospective register of systemic reviews (CRD42020177095) on April 9/2020. |
Author | Mantfardo, Bahiru Abate, Semagn Mekonnen Ahmed Ali, Siraj Basu, Bivash |
AuthorAffiliation | 2 Department of Internal Medicine, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia 1 Department of Anesthesiology, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia Azienda Ospedaliero Universitaria Careggi, ITALY 3 Department of Anesthesiology, College of Medicine, University of Calcutta, Calcutta, India |
AuthorAffiliation_xml | – name: 2 Department of Internal Medicine, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia – name: 1 Department of Anesthesiology, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia – name: 3 Department of Anesthesiology, College of Medicine, University of Calcutta, Calcutta, India – name: Azienda Ospedaliero Universitaria Careggi, ITALY |
Author_xml | – sequence: 1 givenname: Semagn Mekonnen orcidid: 0000-0001-5661-8537 surname: Abate fullname: Abate, Semagn Mekonnen organization: Department of Anesthesiology, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia – sequence: 2 givenname: Siraj surname: Ahmed Ali fullname: Ahmed Ali, Siraj organization: Department of Anesthesiology, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia – sequence: 3 givenname: Bahiru surname: Mantfardo fullname: Mantfardo, Bahiru organization: Department of Internal Medicine, College of Health Sciences and Medicine, Dilla University, Dilla, Ethiopia – sequence: 4 givenname: Bivash surname: Basu fullname: Basu, Bivash organization: Department of Anesthesiology, College of Medicine, University of Calcutta, Calcutta, India |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32649661$$D View this record in MEDLINE/PubMed |
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Copyright | 2020 Abate et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 Abate et al 2020 Abate et al |
Copyright_xml | – notice: 2020 Abate et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2020 Abate et al 2020 Abate et al |
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References | HM Al-Dorzi (pone.0235653.ref023) 2016; 6 C Wu (pone.0235653.ref052) 2020 R-H Du (pone.0235653.ref059) 2020 HM Al-Dorzi (pone.0235653.ref024) 2016; 20 SA Rasmussen (pone.0235653.ref032) 2020 F Zhou (pone.0235653.ref054) 2020 SK Lau (pone.0235653.ref002) 2015 SR Weiss (pone.0235653.ref004) 2005; 69 pone.0235653.ref030 M Arentz (pone.0235653.ref025) 2020 S Richardson (pone.0235653.ref049) 2020 S Lei (pone.0235653.ref057) 2020 HM Al-Dorzi (pone.0235653.ref017) 2016; 6 KW Choi (pone.0235653.ref015) 2003; 139 X-W Xu (pone.0235653.ref042) 2020; 368 A Assiri (pone.0235653.ref029) 2013; 369 D Moher (pone.0235653.ref040) 2009; 6 M Arentz (pone.0235653.ref037) 2020; 323 MA Garbati (pone.0235653.ref065) 2016; 11 D Wang (pone.0235653.ref051) 2020; 323 A Simonnet (pone.0235653.ref050) 2020 D Wu (pone.0235653.ref005) 2020 CM Petrilli (pone.0235653.ref048) 2020 FS Aleanizy (pone.0235653.ref067) 2017; 17 C Huang (pone.0235653.ref047) 2020; 395 COVID C (pone.0235653.ref044) 2020; 69 J Chen (pone.0235653.ref046) 2020 pone.0235653.ref009 PK Bhatraju (pone.0235653.ref043) 2020; 382 AB Docherty (pone.0235653.ref058) 2020; 369 L Ling (pone.0235653.ref060) 2020; 6 AG Aya (pone.0235653.ref068) 2005; 101 C-Y Chen (pone.0235653.ref014) 2005; 68 F Al-Hameed (pone.0235653.ref018) 2016; 31 L-F Wang (pone.0235653.ref003) 2006; 12 N Chen (pone.0235653.ref012) 2020; 395 A Assiri (pone.0235653.ref020) 2013; 369 CC Lai (pone.0235653.ref027) 2020; 55 M Saad (pone.0235653.ref033) 2014; 29 W Liu (pone.0235653.ref041) 2020 AA Halim (pone.0235653.ref026) 2016; 65 AJ Rodriguez-Morales (pone.0235653.ref039) 2020 M Al Ghamdi (pone.0235653.ref066) 2016; 16 J Cao (pone.0235653.ref045) 2020 pone.0235653.ref011 pone.0235653.ref010 GA Almekhlafi (pone.0235653.ref064) 2016; 20 BE Young (pone.0235653.ref006) 2020; 323 FA Klok (pone.0235653.ref056) 2020 J Chan (pone.0235653.ref013) 2003; 58 MJ Cummings (pone.0235653.ref008) 2020 A Zangrillo (pone.0235653.ref061) 2020 SP Adhikari (pone.0235653.ref007) 2020; 9 W-j Guan (pone.0235653.ref053) 2020; 55 GM Joynt (pone.0235653.ref016) 2004; 6 pone.0235653.ref022 J Yang (pone.0235653.ref035) 2020 pone.0235653.ref021 TW Lew (pone.0235653.ref063) 2003; 290 D Wang (pone.0235653.ref034) 2020 C Lodigiani (pone.0235653.ref055) 2020 G Grasselli (pone.0235653.ref062) 2020; 323 X Yang (pone.0235653.ref028) 2020 T Chen (pone.0235653.ref038) 2020; 368 YM Arabi (pone.0235653.ref019) 2014; 160 W Liu (pone.0235653.ref031) 2020 YM Arabi (pone.0235653.ref036) 2020 A Kanwar (pone.0235653.ref001) 2017 |
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Snippet | The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of... Background The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The... BackgroundThe rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The... Background The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The... |
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SubjectTerms | Anesthesiology Betacoronavirus - physiology Biology and life sciences Chi square analysis Chi-square test Comorbidity Complications Coronaviridae Coronavirus Infections - epidemiology Coronavirus Infections - mortality Coronavirus Infections - pathology Coronavirus Infections - physiopathology Coronaviruses COVID-19 Disease transmission Health care Health sciences Heterogeneity Hospitalization Humans Infections Intensive care Intensive Care Units Medicine Medicine and Health Sciences Meta-analysis Middle East respiratory syndrome Middle East Respiratory Syndrome Coronavirus - physiology Morbidity Mortality Pandemics Patients People and Places Physical Sciences Pneumonia Prevalence Regression Analysis Research and Analysis Methods Respiratory diseases Respiratory distress syndrome Risk factors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus - physiology Severity of Illness Index Statistical tests Systematic review Ventilators Viral diseases |
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Title | Rate of Intensive Care Unit admission and outcomes among patients with coronavirus: A systematic review and Meta-analysis |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32649661 https://www.proquest.com/docview/2422400272 https://www.proquest.com/docview/2423065023 https://pubmed.ncbi.nlm.nih.gov/PMC7351172 https://doaj.org/article/91a71ef9af824da2ae595872e5fad9a2 http://dx.doi.org/10.1371/journal.pone.0235653 |
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