Rate of Intensive Care Unit admission and outcomes among patients with coronavirus: A systematic review and Meta-analysis

• Published in: PloS one Vol. 15; no. 7; p. e0235653
• Main Authors: Abate, Semagn Mekonnen, Ahmed Ali, Siraj, Mantfardo, Bahiru, Basu, Bivash
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10-07-2020; Public Library of Science (PLoS)
• Subjects: Anesthesiology; Betacoronavirus - physiology; Biology and life sciences; Chi square analysis; Chi-square test; Comorbidity; Complications; Coronaviridae; Coronavirus Infections - epidemiology; Coronavirus Infections - mortality; Coronavirus Infections - pathology; Coronavirus Infections - physiopathology; Coronaviruses; COVID-19; Disease transmission; Health care; Health sciences; Heterogeneity; Hospitalization; Humans; Infections; Intensive care; Intensive Care Units; Medicine; Medicine and Health Sciences; Meta-analysis; Middle East respiratory syndrome; Middle East Respiratory Syndrome Coronavirus - physiology; Morbidity; Mortality; Pandemics; Patients; People and Places; Physical Sciences; Pneumonia; Prevalence; Regression Analysis; Research and Analysis Methods; Respiratory diseases; Respiratory distress syndrome; Risk factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus - physiology; Severity of Illness Index; Statistical tests; Systematic review; Ventilators; Viral diseases; Middle East; China; Ethiopia
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0235653

The rate of ICU admission among patients with coronavirus varied from 3% to 100% and the mortality was as high as 86% of admitted patients. The objective of the systematic review was to investigate the rate of ICU admission, mortality, morbidity, and complications among patients with coronavirus.
A comprehensive strategy was conducted in PubMed/Medline; Science direct and LILACS from December 2002 to May 2020 without language restriction. The Heterogeneity among the included studies was checked with forest plot, χ2 test, I2 test, and the p-values. All observational studies reporting rate of ICU admission, the prevalence of mortality and its determinants among ICU admitted patients with coronavirus were included and the rest were excluded.
A total of 646 articles were identified from different databases and 50 articles were selected for evaluation. Thirty-seven Articles with 24983 participants were included. The rate of ICU admission was 32% (95% CI: 26 to 38, 37 studies and 32, 741 participants). The Meta-Analysis revealed that the pooled prevalence of mortality in patients with coronavirus disease in ICU was 39% (95% CI: 34 to 43, 37 studies and 24, 983 participants).
The Meta-Analysis revealed that approximately one-third of patients admitted to ICU with severe Coronavirus disease and more than thirty percent of patients admitted to ICU with a severe form of COVID-19 for better care died which warns the health care stakeholders to give attention to intensive care patients.
This Systematic review and Meta-Analysis was registered in Prospero international prospective register of systemic reviews (CRD42020177095) on April 9/2020.