Feasibility and acceptability of a milk and resistance exercise intervention to improve muscle function in community-dwelling older adults (MIlkMAN): Pilot study

• Published in: PloS one Vol. 15; no. 7; p. e0235952
• Main Authors: Granic, Antoneta, Hurst, Christopher, Dismore, Lorelle, Stevenson, Emma, Sayer, Avan A, Aspray, Terry
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10-07-2020; Public Library of Science (PLoS)
• Subjects: Acceptability; Adults; Age; Aged; Aging; Animals; Biology and Life Sciences; Biomedical research; Carbohydrates; Diet; Dietary minerals; Dietary Supplements; Exercise; Feasibility; Feasibility Studies; Female; Gait; Grip strength; Humans; Independent Living; Intervention; Male; Medicine and Health Sciences; Milk; Muscle strength; Muscle Strength - physiology; Musculoskeletal system; Nutrition research; Oils & fats; Older people; People and Places; Pilot Projects; Primary care; Proteins; Quality of Life; R&D; Recruitment; Research & development; Resistance Training; Sarcopenia; Young adults; United Kingdom > UK
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0235952

Dietary protein supplementation combined with resistance exercise (RE) may counteract declines in muscle strength, mass, and function (sarcopenia), but the role of whole foods rich in protein, such as milk, is less well understood. In the MIlkMAN study, we aimed to examine the feasibility and acceptability of milk+RE as an intervention for muscle function in community-dwelling older adults, and provide exploratory pilot data for future substantive research in population at risk of sarcopenia.
In a parallel groups design, 30 older adults (71.7±3.6 years; 12 women) were randomised into three groups: WM (whole milk 3.6% fat)+RE, SM (skimmed milk 0.3% fat)+RE, and C (isocaloric carbohydrate drink)+RE. RE was performed twice-weekly over 6 weeks in a community gym, followed by the consumption of 500 ml of milk (~20 g protein) or carbohydrate drink immediately after exercise and a further 500 ml at home within the following 4-5 hours. The feasibility and acceptability of the study was determined by calculating recruitment and attendance rates, compliance with the intervention, rating participants' experiences, and recording adverse health events.
The response rate was 49% (out of 400 invitations sent), and the recruitment rate was 73.2% (30 participants recruited out of 41 screened for eligibility). Twenty-nine participants completed the intervention-an attendance rate of 97.1%; 89.7% rated their experience as 'excellent'/very good'. Compliance with taking the drinks was 97.1% (WM), 98.3% (SM), and 95.0% (C); 93.1% rated their drink intake as 'easy'/'very easy' with no adverse effects. Collection of exploratory pilot data to inform future trials was successful. Mean change in grip strength, 5-chair rises, and gait speed were 0.9±3.4 kg, 1.8±2.2 s, 0.1±0.1 m/s, respectively with no differences between the groups.
This community-based milk+RE intervention was feasible and acceptable to older adults. The study successfully collected pilot data for future substantive research.