Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes

• Published in: International journal of molecular sciences Vol. 24; no. 20; p. 15080
• Main Authors: Maric, Dusan M, Vojvodic, Danilo, Maric, Dusica L, Velikic, Gordana, Radomir, Mihajlo, Sokolovac, Ivana, Stefik, Debora, Ivkovic, Nemanja, Susnjevic, Sonja, Puletic, Miljan, Dulic, Oliver, Abazovic, Dzihan
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-10-2023; MDPI
• Subjects: Autism; autologous bone marrow aspirate concentrate (BMAC); Biomarkers; Bone marrow; Cytokines; Hypotheses; Immune response; Motor ability; Pathogenesis; Patients; Stem cells; Th1; Th2; Trends; Serbia
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms242015080

Autism spectrum disorder (ASD) has recently been linked to neuroinflammation and an aberrant immune response within the central nervous system. The intricate relationship between immune response and ASD remains elusive, with a gap in understanding the connection between specific immune mechanisms and neural manifestations in autism. In this study, we employed a comprehensive statistical approach, fusing both overarching and granular methods to examine the concentration of 16 cytokines in the cerebrospinal fluid (CSF) across each autologous bone marrow aspirate concentrate (BMAC) intrathecal administration in 63 male and 17 female autism patients. Following a six-month period post the third administration, patients were stratified into three categories based on clinical improvement: Group 1- no/mild (28 subjects), Group 2—moderate (16 subjects), and Group 3—major improvement (15 subjects). Our integrated analysis revealed pronounced disparities in CSF cytokine patterns and clinical outcomes in autism subjects pre- and post-BMAC transplantation. Crucially, our results suggest that these cytokine profiles hold promise as predictive markers, pinpointing ASD individuals who might not exhibit notable clinical amelioration post-BMAC therapy.