The usefulness of an artificial membrane accumulation index for estimation of the bioconcentration factor of organophosphorus pesticides

• Published in: Chemosphere (Oxford) Vol. 74; no. 6; pp. 751 - 757
• Main Authors: Fujikawa, Masaaki, Nakao, Kazuya, Shimizu, Ryo, Akamatsu, Miki
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01-02-2009; Elsevier
• Subjects: absorption; Accumulation; agrochemicals; Applied sciences; artificial membranes; assays; bioaccumulation; bioaccumulation factor; Bioconcentration factor; ecotoxicology; edifenphos; Exact sciences and technology; fish; Freshwater; humans; hydrophobicity; Kinetics; membrane accumulation index; membrane permeability; Membranes, Artificial; Organophosphorus Compounds - chemistry; Organophosphorus pesticide; organophosphorus pesticides; PAMPA; parallel artificial membrane permeation assay; pesticide residues; Pesticides - chemistry; Poecilia reticulata; Pollution; Quantitative Structure-Activity Relationship; Structure–property relationships; water pollution; Argentina, Pampa; PAMPA; Bioconcentration factor; Structure–property relationships; Organophosphorus pesticide; Accumulation; Pollutant behavior; Permeation; Pesticides; Prediction; Hydrophobic compound; Partition coefficient; Permeability; Correlation analysis; Structure-property relationships; Aerosols; Air pollution; Phase partition; Property structure relationship; Biological accumulation; Organic compounds
• ISSN: 0045-6535; 1879-1298
• DOI: 10.1016/j.chemosphere.2008.10.046

The bioconcentration factor (
BCF) is an important ecotoxicological parameter that describes the accumulation of chemicals in organisms. As many studies have reported, log
BCF has good correlation with the logarithm of the 1-octanol/water partition coefficient, log
P
oct, for chemicals that have log
P
oct values below about 6 and are not significantly metabolized in organisms. In this study we measured a membrane accumulation index, that is, the membrane partition (
P
M) of organophosphorus pesticides using the parallel artificial membrane permeation assay (PAMPA) to clarify whether this index is useful for the estimation of
BCF. As a result, log
P
M had good correlation with log
P
oct except for iprobenfos and edifenphos. Furthermore, log
BCF in five kinds of fish, especially male guppy correlated better with log
P
M than log
P
oct. The results indicate that log
P
M is a better index for predicting log
BCF than log
P
oct. We have already reported that PAMPA permeability coefficients could predict human oral absorption of compounds, including hydrophobic chemicals and agrochemicals. Since it is expected that both human oral absorption and
BCF can be estimated simultaneously using PAMPA, PAMPA is useful for exposure estimation to humans of chemicals in the environment.