Experimental and theoretical study of gramicidin P, an analog of gramicidin A with a methylamine C-terminal

Gramicidin P (a gramicidin A in which the ethanolamine C-terminus is replaced by methylamine) was synthesized and shown to have the same single-channel conductance behavior as gramicidin A. The results are discussed in connection with the energy profile computed in the presence of water in compariso...

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Bibliographic Details
Published in:	FEBS letters Vol. 216; no. 1; pp. 11 - 16
Main Authors:	Trudelle, Y., Daumas, P., Heitz, F., Etchebest, C., Pullman, A.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 25-05-1987 Elsevier
Subjects:	Biological and medical sciences Cations Chemical Phenomena Chemistry, Physical Conductance Energy profile Fundamental and applied biological sciences. Psychology Gramicidin - chemical synthesis Gramicidin - pharmacology Gramicidin A analog Gramicidin P Ion Channels lipid bilayers Membrane Potentials - drug effects Membranes, Artificial Molecular biophysics Protein Conformation Structure in molecular biology Structure-Activity Relationship Tridimensional structure Energy profile Conductance Gramicidin A analog Gramicidin P Water Antibiotic Theory Molecular association Ionic channel Cations Conformation
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Summary:	Gramicidin P (a gramicidin A in which the ethanolamine C-terminus is replaced by methylamine) was synthesized and shown to have the same single-channel conductance behavior as gramicidin A. The results are discussed in connection with the energy profile computed in the presence of water in comparison with the corresponding profile for gramicidin A.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(87)80747-0