Effect of kidney disease on glucose handling (including genetic defects)

Reabsorption of glucose in the proximal renal tubule involves the Na+-coupled glucose cotransporter (SGLT) and the facilitative glucose transport (GLUT) multigene glucose transport families. Mutations in SLC5A2, the SGLT2 coding gene, are responsible for familial renal glucosuria (FRG), a genetic di...

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Bibliographic Details
Published in:	Kidney international Vol. 79; no. S120; pp. S7 - S13
Main Authors:	Calado, Joaquim, Santer, René, Rueff, José
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2011 Elsevier Limited
Subjects:	Animals familial renal glucosuria Genetic Association Studies glucose transport Glycosuria - genetics Glycosuria - metabolism Humans Kidney Diseases - genetics Kidney Diseases - metabolism Malabsorption Syndromes Mice Monosaccharide Transport Proteins - genetics SGLT2 SLC5A2 glucose transport familial renal glucosuria SLC5A2 SGLT2
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Summary:	Reabsorption of glucose in the proximal renal tubule involves the Na+-coupled glucose cotransporter (SGLT) and the facilitative glucose transport (GLUT) multigene glucose transport families. Mutations in SLC5A2, the SGLT2 coding gene, are responsible for familial renal glucosuria (FRG), a genetic disorder characterized by glucosuria in the absence of both hyperglycemia and generalized proximal tubular dysfunction. In this paper we focus on FRG and describe other inherited and acquired clinical conditions associated with glucosuria. In addition, a brief review on the regulation of renal glucose transport in diabetes is provided.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0085-2538 0098-6577 1523-1755
DOI:	10.1038/ki.2010.510