Role of Exosomes in Crosstalk Between Cancer-Associated Fibroblasts and Cancer Cells

Cancer-associated fibroblasts (CAFs) are important cells of the tumor microenvironment that can communicate with tumor cells through various mechanisms. Recently, increasing studies have found that exosomes transmit biological information by carrying microRNAs, lncRNAs, proteins, metabolites, and ot...

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Bibliographic Details
Published in:	Frontiers in oncology Vol. 9; p. 356
Main Authors:	Yang, Xi, Li, Yida, Zou, Liqing, Zhu, Zhengfei
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 03-05-2019
Subjects:	cancer-associated fibroblasts crosstalk exosomes lncRNA microRNA Oncology microRNA cancer-associated fibroblasts lncRNA crosstalk exosomes
Online Access:	Get full text
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Summary:	Cancer-associated fibroblasts (CAFs) are important cells of the tumor microenvironment that can communicate with tumor cells through various mechanisms. Recently, increasing studies have found that exosomes transmit biological information by carrying microRNAs, lncRNAs, proteins, metabolites, and other substances, and thus exert biological and therapeutic effects. CAF-secreted exosomes can also affect the tumor phenotype, while the exosomes released by tumor cells can activate CAFs. Here, we review the role of exosomes in the crosstalk between CAFs and tumor cells and elaborate its mechanism.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Maria Letizia Taddei, University of Florence, Italy; Lucie Brisson, Université de Tours, France This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology These authors have contributed equally to this work Edited by: Paolo E. Porporato, University of Turin, Italy
ISSN:	2234-943X 2234-943X
DOI:	10.3389/fonc.2019.00356