Heparin-induced Thrombocytopenia in Essential Thrombocytosis

• Published in: Journal of stroke and cerebrovascular diseases Vol. 21; no. 8; pp. 916.e1 - 916.e5
• Main Authors: Murawaki, Ayumi, MD, Nakayasu, Hiroyuki, MD, Doi, Mitsuru, MD, Suzuki-Kinoshita, Kaori, MD, Asai, Yasumasa, MD, Omura, Hiromi, MD, Nakashima, Kenji, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-11-2012
• Subjects: Aged; Anticoagulants - adverse effects; Anticoagulants - therapeutic use; Argatroban; Arterial Occlusive Diseases - diagnosis; Arterial Occlusive Diseases - etiology; Bone Marrow Examination; Cardiovascular; Cerebral Infarction - diagnosis; Cerebral Infarction - drug therapy; Cerebral Infarction - etiology; Constriction, Pathologic; Diagnosis, Differential; disseminated intravascular coagulation; Disseminated Intravascular Coagulation - diagnosis; essential thrombocytosis; Female; Femoral Artery; Heparin - adverse effects; heparin-induced thrombocytopenia; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Neurology; Pipecolic Acids - therapeutic use; Platelet Aggregation Inhibitors - therapeutic use; Platelet Count; Predictive Value of Tests; Thrombocythemia, Essential - complications; Thrombocythemia, Essential - diagnosis; Thrombocythemia, Essential - therapy; Thrombocytopenia - chemically induced; Thrombocytopenia - diagnosis; Thrombocytopenia - therapy; thromboembolism; Thrombophlebitis - diagnosis; Thrombophlebitis - etiology; Treatment Outcome; Argatroban; essential thrombocytosis; thromboembolism; disseminated intravascular coagulation; heparin-induced thrombocytopenia
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2012.02.011

We report a 67-year-old woman with essential thrombocytosis who developed cerebral infarction and heparin-induced thrombocytopenia during treatment for the cerebral infarction. She developed additional cerebral infarcts, acute femoral artery occlusion, and thrombophlebitis of her lower extremities. She was successfully treated with argatroban. This is the first report of a patient with essential thrombocytosis who developed heparin-induced thrombocytopenia and serious conditions, which included multiple thromboembolisms and coagulation disorders mimicking disseminated intravascular coagulation.