SNAP23 promotes the malignant process of ovarian cancer

• Published in: Journal of ovarian research Vol. 9; no. 1; p. 80
• Main Authors: Sun, Qi, Huang, Xing, Zhang, Quanli, Qu, Junwei, Shen, Yang, Wang, Xin, Sun, Haijun, Wang, Jie, Xu, Lin, Chen, Xiaoxiang, Ren, Binhui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17-11-2016; BioMed Central
• Subjects: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Humans; Neoplasm Invasiveness; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Prognosis; Qb-SNARE Proteins - genetics; Qb-SNARE Proteins - metabolism; Qc-SNARE Proteins - genetics; Qc-SNARE Proteins - metabolism; Up-Regulation; SNAP23; Apoptosis; Ovarian cancer; SNARE
• ISSN: 1757-2215; 1757-2215
• DOI: 10.1186/s13048-016-0289-9

Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC.
We determined the expression of SNAP23 in OC tissues and explored the clinical significance through bioinformatics analysis. The effects of SNAP23 on OC cell proliferation, migration, invasion, cell cycle and apoptosis were then evaluated in vitro.
SNAP23 is hyper-expressed in OC tumor tissues compared to normal tissues, and increased expression of SNAP23 is associated with a poor progression free survival (HR = 1.24, 95% CI = 1.07-1.44, p = 0.0042). SNAP23 knock down increases cell apoptosis and inhibits cell proliferation, migration and invasion of OC cells. GO analysis reveals that most genes correlated highly with SNAP23 were enriched in metabolic process.
Our data suggest that SNAP23 may serve as an oncogene promoting tumorigenicity of OC cells by decreasing apoptotic process.