Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells

• Published in: Expert review of clinical immunology Vol. 11; no. 7; p. 849
• Main Authors: Nguyen, Austin Huy, Berim, Ilya G, Agrawal, Devendra K
• Format: Journal Article
• Language: English
• Published: England 01-07-2015
• Subjects: Animals; Cell Transformation, Neoplastic - immunology; Cell Transformation, Neoplastic - pathology; Chronic Disease; Gene Expression Regulation, Neoplastic - immunology; Humans; Inflammation - immunology; Inflammation - pathology; Myeloid Cells - immunology; Myeloid Cells - pathology; Neoplasm Proteins - immunology; Neoplasms - immunology; Neoplasms - pathology; Receptors, Cell Surface; Signal Transduction - immunology; TREM-2; TREM-1; leukemia; colorectal cancer; triggering receptor expressed on myeloid cells; neoplastic disease; non small cell lung cancer; chronic inflammation; hepatocellular carcinoma; inflammatory bowel disease
• ISSN: 1744-8409
• DOI: 10.1586/1744666X.2015.1043893

Inflammation is tightly regulated by a vast system that is intricately interconnected with innate immunity. Aberrations in expression or signaling, such as in innate immune receptors, can create excessive inflammation and, when chronic, often promote oncogenesis. The triggering receptor expressed on myeloid cells receptor family has been characterized as a major player in the amplification and signaling of the inflammatory response. In a number of chronic inflammatory conditions and malignancies, the triggering receptor expressed on myeloid cells has been implicated in disease severity and progression. In this article, the current understanding of triggering receptor expressed on myeloid cells function in pre-malignant, malignant and chronic inflammatory conditions is critically reviewed. The potential for therapeutic application is also discussed.