Alternative Synthesis of Substance P

A bovine hypothalamic peptide, substance P was synthesized alternatively by successive condensation of three subunits, N-terminal di-, middle hepta- and C-terminal dipeptides. Two newly synthesized peptides, PCA-Phe-Phe-Gly-Leu-Met-NH2 and PCA-Gln-Phe-Phe-Gly-Leu-Met-NH2 were both found to be approx...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 26; no. 5; pp. 1604 - 1607
Main Authors:	KITAGAWA, KOUKI, BAN, YUKO, AKITA, TADASHI, SEGAWA, TOMIO, NAKATA, YOSHIHIRO, YAJIMA, HARUAKI
Format:	Journal Article
Language:	English
Published:	Tokyo The Pharmaceutical Society of Japan 01-01-1978 Japan Science and Technology Agency
Subjects:	smooth muscle contractile activity
Online Access:	Get full text
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Summary:	A bovine hypothalamic peptide, substance P was synthesized alternatively by successive condensation of three subunits, N-terminal di-, middle hepta- and C-terminal dipeptides. Two newly synthesized peptides, PCA-Phe-Phe-Gly-Leu-Met-NH2 and PCA-Gln-Phe-Phe-Gly-Leu-Met-NH2 were both found to be approximately two times active than synthetic substance P, when the contractile activity was determined in isolated guinea-pig ileum.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.26.1604