Agonistic effect of imidazole and triazole fungicides on in vitro oocyte maturation in rainbow trout ( Oncorhynchus mykiss)

• Published in: Marine environmental research Vol. 58; no. 2; pp. 143 - 146
• Main Authors: Monod, Gilles, Rime, Hélène, Bobe, Julien, Jalabert, Bernard
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Elsevier Ltd 01-08-2004; Elsevier; Elsevier science
• Subjects: Animal and plant ecology; Animal, plant and microbial ecology; Animals; Biological and medical sciences; Computer Science; Dactinomycin - pharmacology; Dose-Response Relationship, Drug; Female; Fundamental and applied biological sciences. Psychology; Fungicides, Industrial - antagonists & inhibitors; Fungicides, Industrial - toxicity; Imidazoles - antagonists & inhibitors; Imidazoles - toxicity; In Vitro Techniques; Life Sciences; Oncorhynchus mykiss; Oncorhynchus mykiss - growth & development; Oncorhynchus mykiss - metabolism; Oocytes - drug effects; Oocytes - growth & development; Protein Synthesis Inhibitors - pharmacology; Sea water ecosystems; Sexual Maturation - drug effects; Synecology; Triazoles - antagonists & inhibitors; Triazoles - toxicity; Marine environment; Vertebrata; Germinal cell; Oncorhynchus mykiss; Pisces; Oocyte
• ISSN: 0141-1136; 1879-0291
• DOI: 10.1016/j.marenvres.2004.03.008

The purpose of the present study was to assess the in vitro effect of some imidazole (prochloraz, imazalil) and triazole (epoxiconazole) agricultural fungicides on gonadotropin-induced oocyte maturation in rainbow trout. Results show that prochloraz, epoxiconazole and imazalil strongly potentiated the induction of oocyte maturation by gonadotropin in a dose-dependent manner. Furthermore, 10
−5 M prochloraz and epoxiconazole alone induced oocyte maturation. The mRNA biosynthesis inhibitor, actinomycin
d, completely inhibited oocyte maturation induced by fungicides, suggesting that the gonadotropin-like effect of these chemicals is at least dependent on de novo gene expression.