Basophils exhibit antibacterial activity through extracellular trap formation

Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report...

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Bibliographic Details
Published in:	Allergy (Copenhagen) Vol. 70; no. 9; pp. 1184 - 1188
Main Authors:	Yousefi, S., Morshed, M., Amini, P., Stojkov, D., Simon, D., Gunten, S., Kaufmann, T., Simon, H.‐U.
Format:	Journal Article
Language:	English
Published:	Denmark Blackwell Publishing Ltd 01-09-2015
Subjects:	Allergies Animals Bacteria Bacteria - immunology basophil extracellular trap basophils Basophils - immunology Basophils - metabolism Basophils - microbiology extracellular bacterial killing Extracellular Traps - immunology Extracellular Traps - microbiology Humans Hypersensitivity - immunology Hypersensitivity - microbiology Immunomodulation innate immunity Mice Neutrophils - immunology Neutrophils - metabolism Neutrophils - microbiology phagocytosis Phagocytosis - immunology phagocytosis basophils extracellular bacterial killing basophil extracellular trap innate immunity
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Summary:	Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0105-4538 1398-9995
DOI:	10.1111/all.12662