The sweet and sour of cancer: glycans as novel therapeutic targets

A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation, invasion, haematogenous metastasis and angiogenesis, and increased understanding of these roles sets the stage for developing pharmaceutical...

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Bibliographic Details
Published in:	Nature reviews. Cancer Vol. 5; no. 7; pp. 526 - 542
Main Authors:	Esko, Jeffrey D, Fuster, Mark M
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-07-2005
Subjects:	Cancer Cancer cells Care and treatment Cell Proliferation Disease Progression Health aspects Humans Methods Neoplasm Invasiveness - physiopathology Neoplasm Metastasis - physiopathology Neoplasms - immunology Neoplasms - pathology Neoplasms - physiopathology Neoplastic Processes Neovascularization, Pathologic - physiopathology Physiological aspects Polysaccharides Polysaccharides - physiology Tumor Escape - immunology United States
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Summary:	A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation, invasion, haematogenous metastasis and angiogenesis, and increased understanding of these roles sets the stage for developing pharmaceutical agents that target these molecules. Such novel agents might be used alone or in combination with operative and/or chemoradiation strategies for treating cancer.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Review-2
ISSN:	1474-175X 1474-1768
DOI:	10.1038/nrc1649