Human Papillomavirus Prevalence and Genotype Distribution among Turkish Women with or Without Cervical Lesion

• Published in: Indian journal of medical microbiology Vol. 36; no. 4; pp. 517 - 521
• Main Authors: Demirci, Mehmet, Guzel, Aylin Dag, Ersahin, Aynur Adeviye, Yorulmaz, Eda, Ersahin, Suat Suphan, Borsa, Baris Ata
• Format: Journal Article
• Language: English
• Published: United States Elsevier B.V 01-10-2018; Wolters Kluwer India Pvt. Ltd; Elsevier Limited
• Subjects: Adult; Age groups; Aged; Aged, 80 and over; Cancer; Cellular biology; Cervical cancer; Cervical lesion; Cervix; Condylomata Acuminata - virology; Cytological Techniques; Cytology; Deoxyribonucleic acid; DNA; Female; Genotype; Genotype & phenotype; Genotypes; Genotyping Techniques; Gynecology; Health risks; Human papillomavirus; Humans; Infections; Lesions; Medical screening; Middle Aged; Obstetrics; Papillomaviridae - classification; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - epidemiology; Papillomavirus Infections - virology; Patients; Prevalence; Risk; Studies; Turkey - epidemiology; Uterine Neoplasms - virology; Vaccines; Viral infections; Womens health; Young Adult; Turkey; United States > US; Mannheim Germany; Cervical lesion; human papillomavirus; genotype
• ISSN: 0255-0857; 1998-3646; 1998-3646
• DOI: 10.4103/ijmm.IJMM_18_232

Context: Human papillomavirus (HPV) infection is the main cause of cervical cancer, but the risk is associated with the various HPV genotypes which may be found in women with or without clinical findings. Aims: We aimed to identify HPV prevalence and genotype distribution in women with or without cervical lesions admitted to Gynaecology and Obstetrics Clinics of one of the largest private hospitals in Istanbul between 2013 and 2017. Subjects and Methods: In the present study, cervical cytobrush samples collected from 2464 women with different cytological conditions, and investigated for the presence of HPV, and the different genotypes. Results were evaluated based on the HPV positivity in different cytological findings, and ages. Furthermore, distribution of high-risk (HR) and low-risk (LR) genotypes in different groups was investigated. Results: Among all participants, 1925 (78.1%) was with the normal cytological condition, 354 (14.4%) with ASC-US; 151 (6.1%) with low-grade squamous intraepithelial lesion (LSIL), and 34 (1.4%) with high-grade squamous intraepithelial lesion (HSIL). Our results showed that 649 out of 2464 patients (26.3%) were positive, and 1815 (73.7%) were negative for the presence of HPV. Among 649 positive patients, 223 (34.3%) were found positive for more than one genotype. HPV 16 was found the most common HR-HPV type in ASC-US and LSIL whereas HPV 18 was the most common in HSIL. HPV 6 was found the most common LR-HPV type in ASC-US and LSIL whereas HPV 11 was the most common in HSIL. 26.9% of women <50 years old, and 22.3% of women ≥50 years old was positive for HPV. The most common HR-HPV genotype was 16 in both groups with (19%) or without (17%) abnormal cytology. Conclusions: We concluded that HPV prevalence and genotype distribution in women with or without clinical findings is an important predictor of cervical cancer.