Social factors modulate restraint stress induced hyperthermia in mice

• Published in: Brain research Vol. 1624; pp. 134 - 139
• Main Author: Watanabe, Shigeru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 22-10-2015
• Subjects: Animals; Body Temperature; Corticosterone - blood; Empathy; Fever - etiology; Hyperthermia; Mice; Mice, Inbred ICR; Neurology; Restraint stress; Restraint, Physical - adverse effects; Social Behavior; Social factors; Social inequality; Stress, Psychological - physiopathology; Stress, Psychological - psychology; Time Factors; Restraint stress; Social inequality; Social factors; Empathy; Hyperthermia
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2015.07.019

Abstract Stress-induced hyperthermia (SIH) was examined in three different social conditions in mice by thermographic measurement of the body surface temperature. Placing animals in cylindrical holders induced restraint stress. I examined the effect of the social factors in SIH using the thermograph (body surface temperature). Mice restrained in the holders alone showed SIH. Mice restrained in the holders at the same time as other similarly restrained cage mates (social equality condition) showed less hyperthermia. Interestingly, restrained mice with free moving cage mates (social inequality condition) showed the highest hyperthermia. These results are consistent with a previous experiment measuring the memory-enhancing effects of stress and the stress-induced elevation of corticosterone, and suggest that social inequality enhances stress.