Leukocyte and Fibroblast Interferon Genes are Located on Human Chromosome 9

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 78; no. 5; pp. 3123 - 3127
• Main Authors: Owerbach, David, Rutter, William J., Shows, Thomas B., Gray, Patrick, Goeddel, David V., Lawn, Richard M.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01-05-1981; National Acad Sciences
• Subjects: Animals; Cell Line; Cell lines; Chromosomes; Chromosomes, Human - metabolism; Chromosomes, Human, 6-12 and X - metabolism; Clone Cells - metabolism; DNA; DNA Restriction Enzymes; Fibroblasts; Fibroblasts - metabolism; Genes; Human chromosomes; Humans; Hybrid Cells - metabolism; Hybridity; Interferons; Interferons - genetics; Leukocytes; Leukocytes - metabolism; Mice; Nucleic Acid Hybridization; Somatic cells
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.78.5.3123

At least eight leukocyte interferon genes (IFL) and the single fibroblast interferon gene (IFF) have been located on chromosome 9 in humans. In somatic cell hybrids of human and mouse cells containing a normal complement of mouse parental cell chromosomes but reduced numbers of human chromosomes, the human leukocyte and fibroblast interferon DNA sequences were present only when human chromosome 9 was also present.