A twin study of body mass index and dental caries in childhood

• Published in: Scientific reports Vol. 10; no. 1; p. 568
• Main Authors: Silva, M. J., Kilpatrick, N. M., Craig, J. M., Manton, D. J., Leong, P., Ho, H., Saffery, R., Burgner, D. P., Scurrah, K. J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17-01-2020; Nature Publishing Group
• Subjects: 692/308/3187; 692/699/3017/3018; Body Mass Index; Child; Children; Dental caries; Dental Caries - epidemiology; Diseases in Twins - epidemiology; Female; Fluoridation; Humanities and Social Sciences; Humans; Infant; Logistic Models; Male; multidisciplinary; Nutritional Status; Science; Science (multidisciplinary); Statistical analysis; Statistical methods; Statistics; Teeth; Twin studies; Twins
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-57435-7

Sub-optimal nutrition and dental caries are both common with significant short and long-term implications for child health and development. We applied twin statistical methods to explore the relationship between body mass index (BMI) and dental caries. We measured BMI at 18 months and six years of age and cumulative dental caries experience at six years in 344 twin children. Dental caries in primary teeth was categorised into ‘any’ or ‘advanced’ and BMI was analysed as both a continuous and categorical variable. Statistical analyses included multiple logistic regression using generalized estimating equations and within/between-pair analyses. There was no association between BMI and ‘any’ dental caries experience at either time-point, neither overall nor in within/between pair analyses. However, ‘advanced’ dental caries at six years was associated with a within-pair difference in BMI of −0.55 kg/m
2
(95% CI −1.00, −0.11, p = 0.015). A within-pair increase of 1 kg/m
2
in BMI was associated with a lower within-pair risk of advanced dental caries (OR 0.68, 95% CI 0.52, 0.90, p = 0.007). These findings reveal a possible causal relationship between lower BMI and dental caries. As dental outcomes were only measured at one time point, the direction of this potentially causal relationship is unclear.