Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

• Published in: Nanomaterials (Basel, Switzerland) Vol. 12; no. 16; p. 2869
• Main Authors: Ramírez-Morales, Maria Antonieta, Goldt, Anastasia E, Kalachikova, Polina M, Ramirez B., Javier A, Suzuki, Masashi, Zhigach, Alexey N, Ben Salah, Asma, Shurygina, Liliya I, Shandakov, Sergey D, Zatsepin, Timofei, Krasnikov, Dmitry V, Maekawa, Toru, Nikolaev, Evgeny N, Nasibulin, Albert G
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-08-2022; MDPI
• Subjects: Albumin; Biocompatibility; Bovine serum albumin; Cancer therapies; Carbon; Condensates; Core-shell particles; core–shell nanoparticles; Electromagnetic properties; Electromagnetism; Evaporation; ferromagnetic particles; Fever; flow-levitation method; Heat; Heat generation; High temperature; Hyperthermia; Iron; iron nanoparticles; Levitation; Low concentrations; Magnetic fields; magnetic hyperthermia; Magnetic properties; Nanoparticles; Serum albumin; Japan; Russia; United Kingdom > UK; United States > US
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano12162869

Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.